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marc-3 E3 ubiquitin-protein ligase marc-3 [ Caenorhabditis elegans ]

Gene ID: 172767, updated on 2-Nov-2024

Summary

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Official Symbol
marc-3
Official Full Name
E3 ubiquitin-protein ligase marc-3
Primary source
WormBase:WBGene00007643
Locus tag
CELE_C17E4.3
See related
AllianceGenome:WB:WBGene00007643
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in membrane. Is expressed in accessory cell; intestine; and pharyngeal muscle cell. Orthologous to several human genes including MARCHF3 (membrane associated ring-CH-type finger 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See marc-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (9416704..9418885, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cilia- and flagella-associated protein 157 Neighboring gene HOOK domain-containing protein Neighboring gene ABC2_membrane domain-containing protein Neighboring gene Methyltransferase domain-containing protein Neighboring gene RRM domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MARC-3, a membrane-associated ubiquitin ligase, is required for fast polyspermy block in Caenorhabditis elegans. Kawasaki I, et al. Nat Commun, 2024 Jan 26. PMID 38278786, Free PMC Article
  2. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MARC-3, a membrane-associated ubiquitin ligase, is required for fast polyspermy block in Caenorhabditis elegans.
    Title: MARC-3, a membrane-associated ubiquitin ligase, is required for fast polyspermy block in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase marc-3
NP_492502.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9416704..9418885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060101.5 → NP_492502.2  E3 ubiquitin-protein ligase marc-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492502.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93227
    Conserved Domains (2) summary
    cd00162
    Location:13 → 67
    RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
    cl17238
    Location:12 → 71
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein
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