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pabp-2 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172768, updated on 2-Nov-2024

Summary

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Official Symbol
pabp-2
Official Full Name
RRM domain-containing protein
Primary source
WormBase:WBGene00003904
Locus tag
CELE_C17E4.5
See related
AllianceGenome:WB:WBGene00003904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable poly(A) binding activity. Predicted to be active in nucleus. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to several human genes including PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pabp-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (9420912..9421992, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase marc-3 Neighboring gene Methyltransferase domain-containing protein Neighboring gene ABC2_membrane domain-containing protein Neighboring gene Vacuolar protein sorting-associated protein 72 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The type II poly(A)-binding protein PABP-2 genetically interacts with the let-7 miRNA and elicits heterochronic phenotypes in Caenorhabditis elegans. Hurschler BA, et al. Nucleic Acids Res, 2011 Jul. PMID 21415013, Free PMC Article
  2. UBR-5 and UBE2D mediate timely exit from stem fate via destabilization of poly(A)-binding protein PABP-2 in cell state transition. Calva Moreno JF, et al. Proc Natl Acad Sci U S A, 2024 Oct 22. PMID 39405353, Free PMC Article
  3. LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay. Mattout A, et al. Nat Cell Biol, 2020 May. PMID 32251399, Free PMC Article
  4. MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans. Huang NN, et al. Development, 2002 Feb. PMID 11830574
  5. High-throughput in vivo analysis of gene expression in Caenorhabditis elegans. Hunt-Newbury R, et al. PLoS Biol, 2007 Sep. PMID 17850180, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBR-5 and UBE2D mediate timely exit from stem fate via destabilization of poly(A)-binding protein PABP-2 in cell state transition.
    Title: UBR-5 and UBE2D mediate timely exit from stem fate via destabilization of poly(A)-binding protein PABP-2 in cell state transition.
  2. Depletion of PABP-2 by RNA interference suppresses loss of let-7 activity, and, in let-7 wild-type animals, leads to precocious differentiation of seam cells.
    Title: The type II poly(A)-binding protein PABP-2 genetically interacts with the let-7 miRNA and elicits heterochronic phenotypes in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_492504.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9420912..9421992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060103.8 → NP_492504.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492504.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93233
    Conserved Domains (1) summary
    cl17169
    Location:79 → 154
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
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