mec-8 RRM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mec-8
Official Full Name: RRM domain-containing protein
Primary source: WormBase:WBGene00003172
Locus tag: CELE_F46A9.6
See related: AllianceGenome:WB:WBGene00003172
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity. Involved in several processes, including hemidesmosome assembly; mechanosensory behavior; and nematode larval development. Located in nucleus. Is expressed in several structures, including head muscle; hypodermis; intestine; nervous system; and vulva. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor) and RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mec-8 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (9441010..9444227, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here we combine RNA-seq with in vitro binding assays to study how 4 different C. elegans SFs, ASD-1, FOX-1, MEC-8, and EXC-7, regulate splicing. The 4 SFs chosen all have well-characterised biology and well-studied loss-of-function genetic alleles, and all contain RRM domains
Title: The combinatorial control of alternative splicing in C. elegans.
Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family has been reported.
Title: Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family.
Inclusion of mec-2 intron 9 is sufficient to convey mec-8-dependent regulation on other genes and, in mec-8(u218ts) mutants, resulted in their temperature-dependent expression
Title: Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C17E4.11 (e-PCR)
- UniSTS:319051

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemidesmosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RRM domain-containing protein

NP_492508.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9441010..9444227 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060107.7 → NP_492508.1 RRM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492508.1

Status: REVIEWED

UniProtKB/TrEMBL

G5ECJ4, Q22039

Conserved Domains (3) summary

COG0724
Location:214 → 306

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12245
Location:226 → 304

RRM_scw1_like; RNA recognition motif in yeast cell wall integrity protein scw1 and similar proteins

cl17169
Location:30 → 112

RRM_SF; RNA recognition motif (RRM) superfamily