ile-1 L-type lectin-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ile-1
Official Full Name: L-type lectin-like domain-containing protein
Primary source: WormBase:WBGene00002070
Locus tag: CELE_K07A1.8
See related: AllianceGenome:WB:WBGene00002070
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable D-mannose binding activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to several human genes including LMAN1 (lectin, mannose binding 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ile-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (9609544..9611534, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K07A1.8 (e-PCR)
- UniSTS:321565

K07A1.9 (e-PCR)
- UniSTS:307776

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables D-mannose binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: L-type lectin-like domain-containing protein

NP_492548.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9609544..9611534 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060147.7 → NP_492548.1 L-type lectin-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492548.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDE8

Conserved Domains (2) summary

cd06902
Location:26 → 250

lectin_ERGIC-53_ERGL; ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain

pfam06785
Location:250 → 346

UPF0242; Uncharacterized protein family (UPF0242)