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dhs-4 DeHydrogenases, Short chain [ Caenorhabditis elegans ]

Gene ID: 172810, updated on 2-Nov-2024

Summary

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Official Symbol
dhs-4
Official Full Name
DeHydrogenases, Short chain
Primary source
WormBase:WBGene00000968
Locus tag
CELE_T05F1.10
See related
AllianceGenome:WB:WBGene00000968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be active in lipid droplet. Orthologous to human SDR16C5 (short chain dehydrogenase/reductase family 16C member 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dhs-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (9647603..9649238, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Phosphate carrier protein, mitochondrial Neighboring gene Uncharacterized protein Neighboring gene F-box associated domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene protein-disulfide reductase Neighboring gene Long arms of the bivalent protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hydroxysteroid dehydrogenase family proteins on lipid droplets through bacteria, C. elegans, and mammals. Liu Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Aug. PMID 29702244
  2. Systematic temperature signaling regulates behavior plasticity. Li Y. Protein Cell, 2011 Oct. PMID 22058030, Free PMC Article
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DeHydrogenases, Short chain
NP_492563.1
  • Product from WormBase gene class dhs;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9647603..9649238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060162.4 → NP_492563.1  DeHydrogenases, Short chain [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492563.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18030
    Conserved Domains (2) summary
    cd05339
    Location:43 → 286
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    pfam00106
    Location:41 → 235
    adh_short; short chain dehydrogenase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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