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npp-14 Nuclear pore complex protein 14 [ Caenorhabditis elegans ]

Gene ID: 172813, updated on 2-Nov-2024

Summary

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Official Symbol
npp-14
Official Full Name
Nuclear pore complex protein 14
Primary source
WormBase:WBGene00003800
Locus tag
CELE_C03D6.4
See related
AllianceGenome:WB:WBGene00003800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables caspase binding activity. Involved in inhibition of cysteine-type endopeptidase activity involved in apoptotic process and negative regulation of execution phase of apoptosis. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Orthologous to human NUP214 (nucleoporin 214). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See npp-14 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (9660174..9664915, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene protein-disulfide reductase Neighboring gene Long arms of the bivalent protein 1 Neighboring gene putative histone chaperone asf-1-like protein Neighboring gene Aa_trans domain-containing protein Neighboring gene mRNA guanylyltransferase Neighboring gene Piwi domain-containing protein Neighboring gene putative ribosome biogenesis protein RLP24

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14. Chen X, et al. Nat Struct Mol Biol, 2016 Nov. PMID 27723735, Free PMC Article
  2. Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos. Nkombo Nkoula S, et al. Sci Adv, 2023 Jul 21. PMID 37467327, Free PMC Article
  3. PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline. Pushpa K, et al. Development, 2013 Mar. PMID 23444359, Free PMC Article
  4. Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo. Galy V, et al. Mol Biol Cell, 2003 Dec. PMID 12937276, Free PMC Article
  5. Analysis of Nuclear Pore Complexes in Caenorhabditis elegans by Live Imaging and Functional Genomics. de la Cruz Ruiz P, et al. Methods Mol Biol, 2022. PMID 35412238

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables caspase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inhibition of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear pore complex protein 14
NP_492568.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9660174..9664915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060167.7 → NP_492568.1  Nuclear pore complex protein 14 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492568.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17602
    Conserved Domains (3) summary
    pfam16755
    Location:271 → 400
    NUP214; Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
    pfam13634
    Location:1289 → 1373
    Nucleoporin_FG; Nucleoporin FG repeat region
    cl25732
    Location:532 → 757
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17602.1

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