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gfi-2 ANK_REP_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172825, updated on 2-Nov-2024

Summary

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Official Symbol
gfi-2
Official Full Name
ANK_REP_REGION domain-containing protein
Primary source
WormBase:WBGene00001582
Locus tag
CELE_K02A11.1
See related
AllianceGenome:WB:WBGene00001582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be active in cytoplasm. Orthologous to human PPP1R16A (protein phosphatase 1 regulatory subunit 16A) and PPP1R16B (protein phosphatase 1 regulatory subunit 16B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gfi-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (9737816..9744146)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SPOR domain-containing protein Neighboring gene Endoribonuclease endu-1 Neighboring gene Saposin B-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Choe KP, et al. Am J Physiol Cell Physiol, 2008 Dec. PMID 18829898, Free PMC Article
  2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ANK_REP_REGION domain-containing protein
NP_001366793.1
  • Confirmed by transcript evidence
NP_001366991.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9737816..9744146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381135.1 → NP_001366991.1  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95ZS1
    Conserved Domains (3) summary
    PHA03095
    Location:69 → 290
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:61 → 87
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:53 → 153
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001381136.3 → NP_001366793.1  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    P90902
    Conserved Domains (3) summary
    PHA03095
    Location:69 → 290
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:61 → 87
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:53 → 153
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
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