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drsh-1 Ribonuclease 3 [ Caenorhabditis elegans ]

Gene ID: 172830, updated on 2-Nov-2024

Summary

Official Symbol
drsh-1
Official Full Name
Ribonuclease 3
Primary source
WormBase:WBGene00009163
Locus tag
CELE_F26E4.10
See related
AllianceGenome:WB:WBGene00009163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ribonuclease III activity. Involved in primary miRNA processing and sexual reproduction. Predicted to be part of microprocessor complex. Predicted to be active in nucleus. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See drsh-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (9781324..9785724, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene FAS1 domain-containing protein Neighboring gene ncRNA Neighboring gene Glutathione peroxidase 1 Neighboring gene ncRNA Neighboring gene Tubulin alpha chain Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene COX5B-domain-containing protein

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribonuclease III activity IEA
Inferred from Electronic Annotation
more info
 
enables ribonuclease III activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in primary miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in sexual reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of microprocessor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of microprocessor complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Ribonuclease 3
NP_001122460.2
  • Confirmed by transcript evidence
NP_492599.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9781324..9785724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128988.5NP_001122460.2  Ribonuclease 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122460.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01326
    Conserved Domains (3) summary
    smart00535
    Location:846974
    RIBOc; Ribonuclease III family
    smart00358
    Location:9831056
    DSRM; Double-stranded RNA binding motif
    PRK00102
    Location:8311056
    rnc; ribonuclease III; Reviewed
  2. NM_060198.5NP_492599.1  Ribonuclease 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492599.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8WI03, O01326, O01327, Q9U9Q8
    Conserved Domains (3) summary
    smart00535
    Location:848976
    RIBOc; Ribonuclease III family
    smart00358
    Location:9851058
    DSRM; Double-stranded RNA binding motif
    PRK00102
    Location:8331058
    rnc; ribonuclease III; Reviewed