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nhr-62 NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-62 [ Caenorhabditis elegans ]

Gene ID: 172836, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-62
Official Full Name
NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-62
Primary source
WormBase:WBGene00003652
Locus tag
CELE_Y67A6A.2
See related
AllianceGenome:WB:WBGene00003652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in several processes, including autophagy; regulation of DNA-templated transcription; and triglyceride metabolic process. Predicted to be located in nucleus. Is expressed in several structures, including excretory cell; midbody; neurons; spermatheca; and ventral nerve cord. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-62 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (9839598..9844809)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Phospholipase A1 Neighboring gene ncRNA Neighboring gene Non-histone chromosomal protein HMG-14 Neighboring gene Zwei Ig domain protein zig-1 Neighboring gene mRNA stability protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. Heestand BN, et al. PLoS Genet, 2013. PMID 23935515, Free PMC Article
  2. The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans. Das R, et al. PLoS Genet, 2017 Oct. PMID 29036198, Free PMC Article
  3. Autophagy and Longevity. Nakamura S, et al. Mol Cells, 2018 Jan 31. PMID 29370695, Free PMC Article
  4. H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans. Huang M, et al. Elife, 2022 Sep 20. PMID 36125117, Free PMC Article
  5. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-62
NP_001129799.1
  • Confirmed by transcript evidence
NP_001360798.1
  • Confirmed by transcript evidence
NP_001368765.1
  • Confirmed by transcript evidence
NP_492607.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9839598..9844809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060206.8 → NP_492607.1  Nuclear hormone receptor family member nhr-62 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492607.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3WFY6, O02279
    UniProtKB/TrEMBL
    Q9GTE5
    Conserved Domains (2) summary
    cd06960
    Location:98 → 173
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:299 → 475
    HOLI; Ligand binding domain of hormone receptors

  2. NM_001373584.2 → NP_001360798.1  Nuclear hormone receptor family member nhr-62 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A565CXP8, Q9GTE5
    Conserved Domains (2) summary
    cd06960
    Location:98 → 173
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:299 → 472
    HOLI; Ligand binding domain of hormone receptors

  3. NM_001136327.4 → NP_001129799.1  Nuclear hormone receptor family member nhr-62 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129799.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02279
    Conserved Domains (1) summary
    smart00430
    Location:137 → 313
    HOLI; Ligand binding domain of hormone receptors

  4. NM_001381160.1 → NP_001368765.1  NR LBD domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A565CXN2
    Conserved Domains (1) summary
    smart00430
    Location:137 → 310
    HOLI; Ligand binding domain of hormone receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02279.3

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