nhr-49 NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-49
Official Full Name: NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49
Primary source: WormBase:WBGene00003639
Locus tag: CELE_K10C3.6
See related: AllianceGenome:WB:WBGene00003639
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor binding activity. Involved in determination of adult lifespan; positive regulation of transcription by RNA polymerase II; and regulation of fatty acid metabolic process. Located in cytoplasm and nucleus. Is expressed in hypodermis; intestine; muscle cell; and neurons. Used to study alcohol use disorder and obesity. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-49 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (9869718..9874626)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues.
Title: Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues.
Cell nonautonomous roles of NHR-49 in promoting longevity and innate immunity.
Title: Cell nonautonomous roles of NHR-49 in promoting longevity and innate immunity.
Differentiated 4,4-dimethylsterols from vegetable oils reduce fat deposition depending on the NHR-49/SCD pathway in Caenorhabditis elegans.
Title: Differentiated 4,4-dimethylsterols from vegetable oils reduce fat deposition depending on the NHR-49/SCD pathway in Caenorhabditis elegans.
Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans.
Title: Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans.
NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.
Title: NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.
NHR-49 and MDT-15 enhance expression of skn-1a/c These findings identify a novel role for NHR-49 in ROS detoxification by regulating expression of SKN-1C and phase II detoxification genes.
Title: The Caenorhabditis elegans Oxidative Stress Response Requires the NHR-49 Transcription Factor.
Reduced signaling through the insulin-like receptor daf-2/InsR in the maternal soma causes constitutively large progeny, and its effector daf-16/FoxO is required for this effect. nhr-49/Hnf4, pha-4/FoxA, and skn-1/Nrf also regulate progeny-size plasticity. Genetic analysis suggests that insulin-like signaling controls progeny size in part through regulation of nhr-49/Hnf4, and that pha-4/FoxA and skn-1/Nrf function
Title: Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance.
AAK-2 regulates oxidative metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 transcriptional regulators.
Title: AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators.
NHR-49 may facilitate the adaptation to loss of reproductive potential through synchronized enhancement of fatty-acid oxidation and desaturation,and orchestrating a lipid profile conducive for somatic maintenance and longevity.
Title: Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans.
Data (including data from studies in mutant and transgenic strains) suggest that stress response to fasting (lysosomal lipid accumulation) is co-ordinately regulated by EGL-4/PKG (protein kinase G) and nuclear hormone receptor NHR-49.
Title: PKG and NHR-49 signalling co-ordinately regulate short-term fasting-induced lysosomal lipid accumulation in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K10C3.6 (e-PCR)
- UniSTS:311535

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49

NP_001251234.1

Confirmed by transcript evidence

NP_001367039.1

Confirmed by transcript evidence

NP_001379230.1

Confirmed by transcript evidence

NP_492613.1

Confirmed by transcript evidence

NP_871799.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9869718..9874626

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381165.1 → NP_001367039.1 Nuclear hormone receptor family member nhr-49 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O45666, Q8I4H3, Q8I4H4, Q8WQE4, Q9BJL0, Q9GTG4, Q9GTG5, Q9GTG6, Q9GTG7

Conserved Domains (2) summary

cd06960
Location:35 → 110

NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

smart00430
Location:228 → 382

HOLI; Ligand binding domain of hormone receptors
NM_181999.6 → NP_871799.1 Nuclear hormone receptor family member nhr-49 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871799.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45666

Conserved Domains (2) summary

cd06960
Location:20 → 95

NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

smart00430
Location:213 → 367

HOLI; Ligand binding domain of hormone receptors
NM_060212.8 → NP_492613.1 Nuclear hormone receptor family member nhr-49 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492613.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45666

Conserved Domains (2) summary

cd06960
Location:11 → 86

NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

cl11397
Location:195 → 392

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001392899.1 → NP_001379230.1 Nuclear hormone receptor family member nhr-49 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd06960
Location:11 → 86

NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

smart00430
Location:204 → 358

HOLI; Ligand binding domain of hormone receptors
NM_001264305.3 → NP_001251234.1 NR LBD domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001251234.1

Status: REVIEWED

UniProtKB/TrEMBL

E5QCI8

Conserved Domains (1) summary

cl11397
Location:73 → 270

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators