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oct-1 Organic cation transporter 1 [ Caenorhabditis elegans ]

Gene ID: 172841, updated on 2-Nov-2024

Summary

Official Symbol
oct-1
Official Full Name
Organic cation transporter 1
Primary source
WormBase:WBGene00003842
Locus tag
CELE_F52F12.1
See related
AllianceGenome:WB:WBGene00003842
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables organic cation transmembrane transporter activity. Involved in determination of adult lifespan and organic cation transport. Predicted to be located in membrane. Is expressed in body wall musculature; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; acute kidney failure; cardiomyopathy; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A4 (solute carrier family 22 member 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See oct-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (9888356..9892223, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-5 Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables organic cation transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in organic cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Organic cation transporter 1
NP_001021482.1
  • Confirmed by transcript evidence
NP_492617.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9888356..9892223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060216.6NP_492617.4  Organic cation transporter 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492617.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02270, Q9U539
    Conserved Domains (2) summary
    cd06174
    Location:134526
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:34536
    2A0119; cation transport protein
  2. NM_001026311.7NP_001021482.1  Organic cation transporter 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021482.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U539
    Conserved Domains (2) summary
    cd06174
    Location:117509
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:17519
    2A0119; cation transport protein