oct-1 Organic cation transporter 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: oct-1
Official Full Name: Organic cation transporter 1
Primary source: WormBase:WBGene00003842
Locus tag: CELE_F52F12.1
See related: AllianceGenome:WB:WBGene00003842
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables organic cation transmembrane transporter activity. Involved in determination of adult lifespan and organic cation transport. Predicted to be located in membrane. Is expressed in body wall musculature; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; acute kidney failure; cardiomyopathy; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A4 (solute carrier family 22 member 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See oct-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (9888356..9892223, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CeOCT-1 related members might be key transporters to facilitate entry of anthracyclines into human cells.
Title: Complementation of the Yeast Model System Reveals that Caenorhabditis elegans OCT-1 Is a Functional Transporter of Anthracyclines.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F52F12.1 (e-PCR)
- UniSTS:311726

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables organic cation transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Organic cation transporter 1

NP_001021482.1

Confirmed by transcript evidence

NP_492617.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9888356..9892223 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060216.6 → NP_492617.4 Organic cation transporter 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492617.4

Status: REVIEWED

UniProtKB/Swiss-Prot

O02270, Q9U539

Conserved Domains (2) summary

cd06174
Location:134 → 526

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:34 → 536

2A0119; cation transport protein
NM_001026311.7 → NP_001021482.1 Organic cation transporter 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021482.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U539

Conserved Domains (2) summary

cd06174
Location:117 → 509

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:17 → 519

2A0119; cation transport protein