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epg-8 MRG domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172847, updated on 2-Nov-2024

Summary

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Official Symbol
epg-8
Official Full Name
MRG domain-containing protein
Primary source
WormBase:WBGene00013695
Locus tag
CELE_Y106G6A.2
See related
AllianceGenome:WB:WBGene00013695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol 3-kinase regulator activity and protein-membrane adaptor activity. Involved in macroautophagy; positive regulation of autophagy; and positive regulation of embryonic development. Located in cytoplasm. Is expressed in intestine; neurons; and pharyngeal muscle cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See epg-8 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (9931870..9934290, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Methyltranfer_dom domain-containing protein Neighboring gene START domain-containing protein;Steroidogenic acute regulatory-like protein 1 Neighboring gene BAR domain-containing protein Neighboring gene Dysbindin protein homolog Neighboring gene Protein kinase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The coiled-coil domain protein EPG-8 plays an essential role in the autophagy pathway in C. elegans. Yang P, et al. Autophagy, 2011 Feb. PMID 21116129
  2. Insights into the Neuroprotective Potential of Epicatechin: Effects against Aβ-Induced Toxicity in Caenorhabditis elegans. Ayuda-Durán B, et al. Antioxidants (Basel), 2024 Jan 8. PMID 38247503, Free PMC Article
  3. C. elegans Blastomeres Clear the Corpse of the Second Polar Body by LC3-Associated Phagocytosis. Fazeli G, et al. Cell Rep, 2018 May 15. PMID 29768205
  4. PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. Wu Y, et al. EMBO Rep, 2014 Sep. PMID 25124690, Free PMC Article
  5. Autophagy genes function in apoptotic cell corpse clearance during C. elegans embryonic development. Huang S, et al. Autophagy, 2013 Feb 1. PMID 23108454, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome membrane docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of omegasome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class III IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MRG domain-containing protein
NP_001251254.1
  • Confirmed by transcript evidence
NP_001380108.1
  • Confirmed by transcript evidence
NP_740908.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9931870..9934290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170914.6 → NP_740908.1  MRG domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740908.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XWQ4
    Conserved Domains (1) summary
    TIGR02169
    Location:101 → 221
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_001264325.3 → NP_001251254.1  MRG domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251254.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UBJ1
    Conserved Domains (1) summary
    TIGR02169
    Location:20 → 140
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  3. NM_001392913.1 → NP_001380108.1  MRG domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UBJ2

RNA

  1. NR_002352.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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