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mom-5 Protein mom-5 [ Caenorhabditis elegans ]

Gene ID: 172856, updated on 2-Nov-2024

Summary

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Official Symbol
mom-5
Official Full Name
Protein mom-5
Primary source
WormBase:WBGene00003397
Locus tag
CELE_T23D8.1
See related
AllianceGenome:WB:WBGene00003397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including neuron migration; positive regulation of cell migration; and positive regulation of cellular component organization. Predicted to be located in early endosome and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anus; gonad; hypodermis; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; nonsyndromic congenital nail disorder 1; omodysplasia 2; and schizophrenia. Orthologous to several human genes including FZD1 (frizzled class receptor 1); FZD2 (frizzled class receptor 2); and FZD7 (frizzled class receptor 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mom-5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (9965574..9970037)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase Neighboring gene ncRNA Neighboring gene Tetraspanin Neighboring gene Protein LTV1 homolog Neighboring gene Eukaryotic translation initiation factor 3 subunit C

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans MOM-5/frizzled functions in MOM-2/Wnt-independent cell polarity and is localized asymmetrically prior to cell division. Park FD, et al. Curr Biol, 2004 Dec 29. PMID 15620652
  2. The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells. Levy-Strumpf N, et al. PLoS Genet, 2015 Aug. PMID 26292279, Free PMC Article
  3. The polarity protein VANG-1 antagonizes Wnt signaling by facilitating Frizzled endocytosis. He CW, et al. Development, 2018 Dec 17. PMID 30504124, Free PMC Article
  4. A posterior centre establishes and maintains polarity of the Caenorhabditis elegans embryo by a Wnt-dependent relay mechanism. Bischoff M, et al. PLoS Biol, 2006 Nov. PMID 17121454, Free PMC Article
  5. Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. Langenhan T, et al. Dev Cell, 2009 Oct. PMID 19853563, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Small GTPases mediate MOM-5's regulation of unc-5 such that one outcome of impaired function of small GTPases like CED-10/Rac and MIG-2/RhoG is an increase in unc-5 function.
    Title: The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells.
  2. Study shows that CAM-1 and the Frizzled receptor MOM-5 act in parallel pathways to control the anterior polarization of the mechanosensory neuron ALM.
    Title: Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1.
  3. In a Frizzled-dependent manner, PLR-1 reduces surface levels of the Wnt receptors CAM-1/Ror and LIN-18/Ryk.
    Title: The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.
  4. Rearrangement of mitotic spindles requires the MOM-5/Fz receptor. Apoptotic cell clearance and migration of the distal tip cell require the MOM-5/Fz receptor.
    Title: The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.
  5. C. elegans MOM-5/frizzled functions in MOM-2/Wnt-independent cell polarity and is localized asymmetrically prior to cell division.
    Title: C. elegans MOM-5/frizzled functions in MOM-2/Wnt-independent cell polarity and is localized asymmetrically prior to cell division.
  6. MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.
    Title: MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in Wnt signaling pathway, regulating spindle positioning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic digestive tract morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interneuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in left/right axis specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in left/right axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motor neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuroblast migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of anterior/posterior axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of distal tip cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of distal tip cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of engulfment of apoptotic cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of engulfment of apoptotic cell IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of motor neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of sensory neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Protein mom-5
NP_001300437.1
  • Confirmed by transcript evidence
NP_492635.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9965574..9970037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060234.7 → NP_492635.1  Protein mom-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492635.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AWM6
    Conserved Domains (2) summary
    cd07458
    Location:35 → 147
    CRD_FZ1_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1
    pfam01534
    Location:218 → 548
    Frizzled; Frizzled/Smoothened family membrane region

  2. NM_001313508.3 → NP_001300437.1  Protein mom-5 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AWM6, G5EEF7
    Conserved Domains (2) summary
    cd07458
    Location:35 → 147
    CRD_FZ1_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1
    cd13951
    Location:219 → 550
    7tmF_Frizzled_SMO; class F frizzled/smoothened family, member of the 7-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0K3AWM6.1

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