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mut-16 MUTator [ Caenorhabditis elegans ]

Gene ID: 172873, updated on 2-Nov-2024

Summary

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Official Symbol
mut-16
Official Full Name
MUTator
Primary source
WormBase:WBGene00003508
Locus tag
CELE_B0379.3
See related
AllianceGenome:WB:WBGene00003508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in regulatory ncRNA-mediated post-transcriptional gene silencing and siRNA processing. Located in mutator focus and nucleus. Is expressed in several structures, including germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mut-16 in Genome Data Viewer
Location:
chromosome: I
Exon count:
14
Sequence:
Chromosome: I; NC_003279.8 (10080159..10085765)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene CTD small phosphatase-like protein 1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endogenous RNAi Pathways Are Required in Neurons for Dauer Formation in Caenorhabditis elegans. Bharadwaj PS, et al. Genetics, 2017 Apr. PMID 28122825, Free PMC Article
  2. Tissue-specific silencing of integrated transgenes achieved through endogenous RNA interference in Caenorhabditis elegans. Chen S, et al. RNA Biol, 2024 Jan. PMID 38531838, Free PMC Article
  3. RNAi pathways repress reprogramming of C. elegans germ cells during heat stress. Rogers AK, et al. Nucleic Acids Res, 2020 May 7. PMID 32187370, Free PMC Article
  4. Caenorhabditis elegans germ granules are present in distinct configurations and assemble in a hierarchical manner. Uebel CJ, et al. Development, 2023 Dec 15. PMID 38009921,
  5. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Zhang C, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21245313, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study demonstrate that in C. elegans the assembly of the Mutator complex and the formation of Mutator foci are mediated by the intrinsically disordered protein MUT-16.
    Title: Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci.
  2. MUT-16 is required for expression of a subset of G proteins with functions in the detection of pheromone components.
    Title: Endogenous RNAi Pathways Are Required in Neurons for Dauer Formation in Caenorhabditis elegans.
  3. demonstrate that genes that yield high levels of siRNAs, indicative of multiple rounds of siRNA amplification, are disproportionally affected in mut-16 mutants compared with genes that yield low levels of siRNAs
    Title: MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline.
  4. Results indicate that mut-16 is an essential factor in multiple endogenous germline and somatic siRNA pathways.
    Title: mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mutator focus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MUTator
NP_492660.3
  • Product from WormBase gene class mut;
    Confirmed by transcript evidence
NP_492661.3
  • Product from WormBase gene class mut;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10080159..10085765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060260.9 → NP_492661.3  MUTator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492661.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3S5
    Conserved Domains (2) summary
    pfam07223
    Location:609 → 954
    DUF1421; Protein of unknown function (DUF1421)
    pfam15794
    Location:469 → 609
    CCDC106; Coiled-coil domain-containing protein 106

  2. NM_060259.7 → NP_492660.3  MUTator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492660.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62011
    Conserved Domains (2) summary
    pfam07223
    Location:613 → 958
    DUF1421; Protein of unknown function (DUF1421)
    pfam15794
    Location:473 → 613
    CCDC106; Coiled-coil domain-containing protein 106
Nucleotide Protein
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