lin-11 Protein lin-11 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lin-11
Official Full Name: Protein lin-11
Primary source: WormBase:WBGene00003000
Locus tag: CELE_ZC247.3
See related: AllianceGenome:WB:WBGene00003000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including axonal fasciculation; egg-laying behavior; and positive regulation of vulval development. Predicted to be active in nucleus. Is expressed in several structures, including B.pap; P5.p hermaphrodite; body wall musculature; egg-laying apparatus; and nervous system. Orthologous to several human genes including LHX1 (LIM homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lin-11 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (10248288..10255327)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

neuronal expression of lin-11 involves multiple transcription factor regulators and regulatory modules some of which have diverged in Caenorhabditis nematodes.
Title: Intron-specific patterns of divergence of lin-11 regulatory function in the C. elegans nervous system.
multiple factors cooperate to regulate pi-specific expression of lin-11 and together with other findings suggest that the mechanism of lin-11 regulation by LIN-12/Notch signaling is evolutionarily conserved in Caenorhabditis species.
Title: Dissection of lin-11 enhancer regions in Caenorhabditis elegans and other nematodes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC247.3 (e-PCR)
- UniSTS:322454

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein lin-11

NP_492696.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10248288..10255327

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060295.6 → NP_492696.1 Protein lin-11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492696.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P20154

Conserved Domains (3) summary

cd09375
Location:127 → 182

LIM2_Lhx1_Lhx5; The second LIM domain of Lhx1 (also known as Lim1) and Lhx5

pfam00046
Location:244 → 297

Homeobox; Homeobox domain

pfam00412
Location:68 → 123

LIM; LIM domain