wts-1 Serine/threonine-protein kinase WARTS homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wts-1
Official Full Name: Serine/threonine-protein kinase WARTS homolog
Primary source: WormBase:WBGene00007047
Locus tag: CELE_T20F10.1
See related: AllianceGenome:WB:WBGene00007047
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase activity and transcription coactivator binding activity. Involved in several processes, including apical protein localization; negative regulation of protein import into nucleus; and post-embryonic digestive tract morphogenesis. Located in apical plasma membrane and cytoplasm. Is expressed in several structures, including anal depressor muscle; excretory canal; hypodermis; intestine; and reproductive system. Orthologous to several human genes including LATS1 (large tumor suppressor kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wts-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (10291870..10297927, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WTS-1/LATS regulates endocytic recycling by restraining F-actin assembly in a synergistic manner.
Title: WTS-1/LATS regulates endocytic recycling by restraining F-actin assembly in a synergistic manner.
In summary, we have delineated the conserved Hippo pathway in C. elegans consisting of NFM-1-WTS-1-YAP-1-EGL-44 and proved that the proper regulation of YAP-1 by upstream NFM-1 and WTS-1 is essential for maintenance of apicobasal membrane identities of the growing intestine
Title: The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans.
Genetic analyses show that Ce-wts-1 functions synergistically with the TGF-beta Sma/Mab pathway to regulate body length.
Title: Ce-wts-1 plays important roles in Caenorhabditis elegans development.
Data suggest that WTS-1 kinase plays important roles in the integrity of the apical membrane structure of intestinal cells.
Title: Lats kinase is involved in the intestinal apical membrane integrity in the nematode Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T20F10.1 (e-PCR)
- UniSTS:306283

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein kinase WARTS homolog

NP_492699.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10291870..10297927 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060298.5 → NP_492699.1 Serine/threonine-protein kinase WARTS homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492699.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45797

Conserved Domains (2) summary

smart00220
Location:502 → 807

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05598
Location:500 → 868

STKc_LATS; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor