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sptf-1 Specificity protein transcription factor 1 [ Caenorhabditis elegans ]

Gene ID: 172909, updated on 2-Nov-2024

Summary

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Official Symbol
sptf-1
Official Full Name
Specificity protein transcription factor 1
Primary source
WormBase:WBGene00009743
Locus tag
CELE_F45H11.1
See related
AllianceGenome:WB:WBGene00009743
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and positive regulation of gene expression. Is expressed in several structures, including ASJ; intestinal cell; pharyngeal cell; rectal epithelial cell; and seam cell. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sptf-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (10366621..10371697)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase assembly factor 6 homolog;PRORP domain-containing protein Neighboring gene putative arginine kinase ZC434.8 Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene NEDD8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans. González-Barrios M, et al. Genetics, 2015 May. PMID 25769980, Free PMC Article
  2. A molecular atlas of adult C. elegans motor neurons reveals ancient diversity delineated by conserved transcription factor codes. Smith JJ, et al. Cell Rep, 2024 Mar 26. PMID 38421866, Free PMC Article
  3. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
  4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Specificity protein transcription factor 1
NP_001021465.1
  • Partially confirmed by transcript evidence
NP_001359696.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10366621..10371697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373640.2 → NP_001359696.1  Specificity protein transcription factor 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    sd00019
    Location:262 → 284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260 → 284
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001026294.4 → NP_001021465.1  Specificity protein transcription factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021465.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q564X9, Q93727
    Conserved Domains (3) summary
    sd00019
    Location:262 → 284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260 → 284
    zf-C2H2; Zinc finger, C2H2 type
    cl41771
    Location:162 → 261
    SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93727.2

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