blmp-1 B lymphocyte-induced maturation protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: blmp-1
Official Full Name: B lymphocyte-induced maturation protein 1 homolog
Primary source: WormBase:WBGene00003847
Locus tag: CELE_F25D7.3
See related: AllianceGenome:WB:WBGene00003847
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of distal tip cell migration; positive regulation of nematode male tail tip morphogenesis; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including distal tip cell; dorsal nerve cord; enteric muscle; hypodermis; and neurons. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human PRDM1 (PR/SET domain 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See blmp-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (10409302..10414773)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BLMP-1 is a critical temporal regulator of dietary-restriction-induced response in Caenorhabditis elegans.
Title: BLMP-1 is a critical temporal regulator of dietary-restriction-induced response in Caenorhabditis elegans.
blmp-1 is necessary for controlling histone methylation level in daf-7 mutants, suggesting BLMP-1 regulates the expression of SAMS-1, which in turn may regulate histone methylation and dauer formation.Our results reveal a new interaction between BLMP-1/BLIMP-1 and LIN-40/MTA1, as well as potential epigenetic downstream pathways
Title: BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans.
The roles of positive feedback loops involving blmp-1 and the degradation regulation of DRE-1 has been described.
Title: Noise propagation with interlinked feed-forward pathways.
We identified the zinc finger protein BLMP-1 as a mediator of the HIF-independent response. BLMP-1 is necessary for an increase of hypoxia-dependent histone acetylation within the promoter of a non-HIF-dependent hypoxia response gene.
Title: A HIF-independent mediator of transcriptional responses to oxygen deprivation in Caenorhabditis elegans.
C. elegans blmp-1 was found to act as a transcriptional repressor. Thus, C. elegans BLMP-1 acts as a transcriptional activator or a repressor depending on the context
Title: Direct and positive regulation of Caenorhabditis elegans bed-3 by PRDM1/BLIMP1 ortholog BLMP-1.
Our data suggest evolutionary conservation of these interactions and underscore the importance of DRE-1/FBXO11-mediated BLMP-1/PRDI-BF1 degradation in cellular state transitions during metazoan development.
Title: BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F25D7.3 (e-PCR)
- UniSTS:309931

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of nematode larval development, heterochronic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: B lymphocyte-induced maturation protein 1 homolog

NP_001251370.1

Confirmed by transcript evidence

NP_001251371.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10409302..10414773

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001264441.2 → NP_001251370.1 B lymphocyte-induced maturation protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001251370.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7WN98, Q93560

Conserved Domains (5) summary

smart00317
Location:119 → 247

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

sd00017
Location:510 → 530

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:508 → 530

zf-C2H2; Zinc finger, C2H2 type

pfam04959
Location:620 → 772

ARS2; Arsenite-resistance protein 2

pfam13465
Location:522 → 547

zf-H2C2_2; Zinc-finger double domain
NM_001264442.2 → NP_001251371.1 B lymphocyte-induced maturation protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001251371.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93560

Conserved Domains (6) summary

smart00317
Location:119 → 247

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG5048
Location:469 → 646

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:510 → 530

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:508 → 530

zf-C2H2; Zinc finger, C2H2 type

pfam12067
Location:696 → 745

Sox_C_TAD; Sox C-terminal transactivation domain

pfam13465
Location:522 → 547

zf-H2C2_2; Zinc-finger double domain