F25H2.6 Ceramide transfer protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F25H2.6
Official Full Name: Ceramide transfer protein
Primary source: WormBase:WBGene00009120
Locus tag: CELE_F25H2.6
See related: AllianceGenome:WB:WBGene00009120
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable lipid binding activity. Predicted to be involved in ER to Golgi ceramide transport. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 34. Orthologous to human CERT1 (ceramide transporter 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F25H2.6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (10554366..10557838)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F25H2.5 (e-PCR)
- UniSTS:320518

F25H2.6 (e-PCR)
- UniSTS:314133

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ER to Golgi ceramide transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ceramide transfer protein

NP_492762.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10554366..10557838

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060361.8 → NP_492762.1 Ceramide transfer protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492762.1

Status: REVIEWED

UniProtKB/TrEMBL

Q93569

Conserved Domains (3) summary

cd08872
Location:337 → 573

START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains

cd13283
Location:9 → 109

PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain

pfam00169
Location:11 → 98

PH; PH domain