ubc-25 Ubiquitin-conjugating enzyme E2 25 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ubc-25
Official Full Name: Ubiquitin-conjugating enzyme E2 25
Primary source: WormBase:WBGene00006720
Locus tag: CELE_F25H2.8
See related: AllianceGenome:WB:WBGene00006720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Involved in locomotion. Located in cytosol; neuronal cell body; and nucleus. Is expressed in body wall musculature; embryonic cell; non-striated muscle; and somatic nervous system. Orthologous to several human genes including UBE2Q1 (ubiquitin conjugating enzyme E2 Q1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ubc-25 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (10562970..10564903)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The maintenance of neuromuscular function requires UBC-25.
Title: The maintenance of neuromuscular function requires UBC-25 in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F25H2.8 (e-PCR)
- UniSTS:321402

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ubiquitin-conjugating enzyme E2 25

NP_492764.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10562970..10564903

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060363.7 → NP_492764.2 Ubiquitin-conjugating enzyme E2 25 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492764.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q86M58, Q93571

Conserved Domains (1) summary

smart00212
Location:218 → 376

UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues