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lam-3 Laminin subunit alpha lam-3 [ Caenorhabditis elegans ]

Gene ID: 172952, updated on 2-Nov-2024

Summary

Official Symbol
lam-3
Official Full Name
Laminin subunit alpha lam-3
Primary source
WormBase:WBGene00002248
Locus tag
CELE_T22A3.8
See related
AllianceGenome:WB:WBGene00002248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in animal organ morphogenesis; axonogenesis; and tissue development. Located in basement membrane. Is expressed in several structures, including excretory canal; pharyngeal-intestinal valve; pharynx; somatic nervous system; and spermatheca. Used to study muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA1 (laminin subunit alpha 1) and LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See lam-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (10608466..10621435)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DRBM domain-containing protein Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly Neighboring gene Repressor of RNA polymerase III transcription MAF1 Neighboring gene Protein archease-like

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Laminin subunit alpha lam-3
NP_492775.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10608466..10621435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060374.5NP_492775.2  Laminin subunit alpha lam-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492775.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECE3
    Conserved Domains (10) summary
    smart00136
    Location:42294
    LamNT; Laminin N-terminal domain (domain VI)
    smart00180
    Location:9881033
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:583711
    LamB; Laminin B domain
    smart00282
    Location:22852443
    LamG; Laminin G domain
    COG1842
    Location:18642121
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    cd00055
    Location:16461694
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:24712622
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:10861134
    Laminin_EGF; Laminin EGF domain
    pfam06009
    Location:21572286
    Laminin_II; Laminin Domain II
    cl12013
    Location:18482058
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature