lam-3 Laminin subunit alpha lam-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lam-3
Official Full Name: Laminin subunit alpha lam-3
Primary source: WormBase:WBGene00002248
Locus tag: CELE_T22A3.8
See related: AllianceGenome:WB:WBGene00002248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in animal organ morphogenesis; axonogenesis; and tissue development. Located in basement membrane. Is expressed in several structures, including excretory canal; pharyngeal-intestinal valve; pharynx; somatic nervous system; and spermatheca. Used to study muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA1 (laminin subunit alpha 1) and LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lam-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (10608466..10621435)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Laminin is required to orient epithelial polarity in the C. elegans pharynx.
Title: Laminin is required to orient epithelial polarity in the C. elegans pharynx.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-188 (e-PCR)
- UniSTS:241678

T22A3.8 (e-PCR)
- UniSTS:311634

C43H8.3 (e-PCR)
- UniSTS:319128

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Laminin subunit alpha lam-3

NP_492775.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10608466..10621435

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060374.5 → NP_492775.2 Laminin subunit alpha lam-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492775.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECE3

Conserved Domains (10) summary

smart00136
Location:42 → 294

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:988 → 1033

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:583 → 711

LamB; Laminin B domain

smart00282
Location:2285 → 2443

LamG; Laminin G domain

COG1842
Location:1864 → 2121

PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]

cd00055
Location:1646 → 1694

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2471 → 2622

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1086 → 1134

Laminin_EGF; Laminin EGF domain

pfam06009
Location:2157 → 2286

Laminin_II; Laminin Domain II

cl12013
Location:1848 → 2058

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature