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B0511.6 ATP-dependent RNA helicase [ Caenorhabditis elegans ]

Gene ID: 172954, updated on 2-Nov-2024

Summary

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Official Symbol
B0511.6
Official Full Name
ATP-dependent RNA helicase
Primary source
WormBase:WBGene00015232
Locus tag
CELE_B0511.6
See related
AllianceGenome:WB:WBGene00015232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in P granule. Predicted to be active in nucleolus. Is expressed in head; hypodermis; intestine; pharynx; and tail. Orthologous to human DDX18 (DEAD-box helicase 18). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See B0511.6 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (10625388..10628387)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Repressor of RNA polymerase III transcription MAF1 Neighboring gene Protein archease-like Neighboring gene ZP domain-containing protein Neighboring gene FHA domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P granule IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase
NP_492779.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10625388..10628387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060378.7 → NP_492779.1  ATP-dependent RNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492779.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61815
    Conserved Domains (4) summary
    smart00487
    Location:83 → 291
    DEXDc; DEAD-like helicases superfamily
    cd00268
    Location:68 → 276
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:312 → 407
    Helicase_C; Helicase conserved C-terminal domain
    pfam13959
    Location:450 → 508
    DUF4217; Domain of unknown function (DUF4217)
Nucleotide Protein
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