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ndua-13 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [ Caenorhabditis elegans ]

Gene ID: 172969, updated on 2-Nov-2024

Summary

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Official Symbol
ndua-13
Official Full Name
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Primary source
WormBase:WBGene00016393
Locus tag
CELE_C34B2.8
See related
AllianceGenome:WB:WBGene00016393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 28 and oncocytic carcinoma of the thyroid. Orthologous to human NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ndua-13 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (10685825..10687058, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Signal peptidase complex subunit 1 Neighboring gene Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Neighboring gene KNL (kinetochore null) Binding Protein Neighboring gene AGC-kinase C-terminal domain-containing protein;Structural protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans as a model organism for human mitochondrial associated disorders. Maglioni S, et al. Mitochondrion, 2016 Sep. PMID 26906059
  2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
NP_492799.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10685825..10687058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060398.5 → NP_492799.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492799.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44955
    Conserved Domains (1) summary
    pfam06212
    Location:6 → 135
    GRIM-19; GRIM-19 protein
Nucleotide Protein
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