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spt-16 FACT complex subunit spt-16 [ Caenorhabditis elegans ]

Gene ID: 172984, updated on 2-Nov-2024

Summary

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Official Symbol
spt-16
Official Full Name
FACT complex subunit spt-16
Primary source
WormBase:WBGene00018849
Locus tag
CELE_F55A3.3
See related
AllianceGenome:WB:WBGene00018849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable nucleosome binding activity. Involved in nematode pharynx development; positive regulation of chromosome segregation; and regulation of embryonic development. Located in nucleus. Is expressed in several structures, including intestine. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and thin corpus callosum. Orthologous to human SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spt-16 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (10789130..10793152)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene C2H2-type domain-containing protein Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene Major sperm protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FACT complex gene duplicates exhibit redundant and non-redundant functions in C. elegans. Suggs BZ, et al. Dev Biol, 2018 Dec 15. PMID 30336114, Free PMC Article
  2. Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis. Krüger AV, et al. Dev Biol, 2015 Feb 15. PMID 25446273
  3. CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Sonneville R, et al. Nat Cell Biol, 2017 May. PMID 28368371, Free PMC Article
  4. Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation. Baytek G, et al. Biotechniques, 2022 May. PMID 35297663
  5. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in nematode pharynx development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of FACT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of FACT complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FACT complex subunit spt-16
NP_492821.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10789130..10793152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060420.5 → NP_492821.1  FACT complex subunit spt-16 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492821.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N5R9
    Conserved Domains (5) summary
    COG5406
    Location:8 → 1013
    COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]
    cd01091
    Location:178 → 419
    CDC68-like; Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.
    pfam08512
    Location:808 → 889
    Rtt106; Histone chaperone Rttp106-like
    pfam08644
    Location:534 → 689
    SPT16; FACT complex subunit (SPT16/CDC68)
    pfam14826
    Location:8 → 165
    FACT-Spt16_Nlob; FACT complex subunit SPT16 N-terminal lobe domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N5R9.1

Gene LinkOut

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