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marc-6 RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

Gene ID: 172986, updated on 2-Nov-2024

Summary

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Official Symbol
marc-6
Official Full Name
RING-type E3 ubiquitin transferase
Primary source
WormBase:WBGene00018847
Locus tag
CELE_F55A3.1
See related
AllianceGenome:WB:WBGene00018847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in ERAD pathway and protein polyubiquitination. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Orthologous to human MARCHF6 (membrane associated ring-CH-type finger 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See marc-6 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (10799623..10806925)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FACT complex subunit spt-16 Neighboring gene C2H2-type domain-containing protein Neighboring gene Major sperm protein Neighboring gene tRNA-Asp Neighboring gene Schlafen-like protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in two ERAD E3 ubiquitin ligase enzymes reduce spontaneous reversal frequency in Caenorhabditis elegans. Oswald M, et al. MicroPubl Biol, 2020 Nov 19. PMID 33274327, Free PMC Article
  2. ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans. Sasagawa Y, et al. Genes Cells, 2007 Sep. PMID 17825049
  3. BK channel density is regulated by endoplasmic reticulum associated degradation and influenced by the SKN-1A/NRF1 transcription factor. Cheung TP, et al. PLoS Genet, 2020 Jun. PMID 32502151, Free PMC Article
  4. ER proteostasis regulators cell-non-autonomously control sleep. Kawano T, et al. Cell Rep, 2023 Mar 28. PMID 36924492
  5. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING-type E3 ubiquitin transferase
NP_492823.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10799623..10806925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060422.7 → NP_492823.2  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492823.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4S684, Q400N4
    Conserved Domains (2) summary
    COG5183
    Location:47 → 1016
    SSM4; E3 ubiquitin-protein ligase DOA10 [Posttranslational modification, protein turnover, chaperones]
    cd16702
    Location:52 → 98
    RING_CH-C4HC3_MARCH6; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH6 (MARCH6)
Nucleotide Protein
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