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impt-1 Protein IMPACT homolog [ Caenorhabditis elegans ]

Gene ID: 173001, updated on 2-Nov-2024

Summary

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Official Symbol
impt-1
Official Full Name
Protein IMPACT homolog
Primary source
WormBase:WBGene00013122
Locus tag
CELE_Y52B11A.2
See related
AllianceGenome:WB:WBGene00013122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein sequestering activity. Predicted to be involved in GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of cytoplasmic translational initiation in response to stress. Predicted to be active in cytoplasm. Is expressed in intestine. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See impt-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (10966325..10970177, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene cytochrome-b5 reductase Neighboring gene GTP-binding protein GEM Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. Ferraz RC, et al. BMC Biol, 2016 Oct 7. PMID 27717342, Free PMC Article
  2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein sequestering activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in GCN2-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amino acid starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytoplasmic translational initiation in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein IMPACT homolog
NP_001021782.1
  • Confirmed by transcript evidence
NP_001379419.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10966325..10970177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026611.4 → NP_001021782.1  Protein IMPACT homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021782.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K779, Q9XWF4
    Conserved Domains (2) summary
    smart00591
    Location:10 → 102
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:138 → 247
    UPF0029; Uncharacterized protein family UPF0029

  2. NM_001392943.1 → NP_001379419.1  Protein IMPACT homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    smart00591
    Location:10 → 100
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XWF4.1

Gene LinkOut

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