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dnj-27 DnaJ homolog subfamily C member 10;Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173065, updated on 2-Nov-2024

Summary

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Official Symbol
dnj-27
Official Full Name
DnaJ homolog subfamily C member 10;Thioredoxin domain-containing protein
Primary source
WormBase:WBGene00001045
Locus tag
CELE_Y47H9C.5
See related
AllianceGenome:WB:WBGene00001045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable misfolded protein binding activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; and protein-disulfide reductase activity. Involved in IRE1-mediated unfolded protein response. Located in endoplasmic reticulum lumen. Is expressed in several structures, including body wall musculature; intestine; pharynx; rectum; and reproductive system. Orthologous to human DNAJC10 (DnaJ heat shock protein family (Hsp40) member C10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dnj-27 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (11877803..11887278)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Palmitoyltransferase Neighboring gene Cell death abnormality protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Translation initiation factor eIF2B subunit beta Neighboring gene Non-catalytic caspase homolog csp-3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases. Muñoz-Lobato F, et al. Antioxid Redox Signal, 2014 Jan 10. PMID 23641861, Free PMC Article
  2. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in IRE1-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IRE1-mediated unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DnaJ homolog subfamily C member 10;Thioredoxin domain-containing protein
NP_001040704.1
  • Confirmed by transcript evidence
NP_001040705.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    11877803..11887278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047239.4 → NP_001040704.1  DnaJ homolog subfamily C member 10 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040704.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XWE1
    Conserved Domains (6) summary
    COG0484
    Location:18 → 150
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cd03003
    Location:116 → 214
    PDI_a_ERdj5_N; PDIa family, N-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is comprised of the first TRX domain of ERdj5 located after the ...
    cd03004
    Location:549 → 664
    PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...
    TIGR01130
    Location:438 → 750
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    pfam00226
    Location:20 → 82
    DnaJ; DnaJ domain
    cl00388
    Location:222 → 312
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  2. NM_001047240.3 → NP_001040705.1  Thioredoxin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040705.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q25AR9
    Conserved Domains (2) summary
    cd03004
    Location:79 → 194
    PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...
    cl00388
    Location:1 → 73
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
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