ubc-12 NEDD8-conjugating enzyme ubc-12 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ubc-12
Official Full Name: NEDD8-conjugating enzyme ubc-12
Primary source: WormBase:WBGene00006707
Locus tag: CELE_R09B3.4
See related: AllianceGenome:WB:WBGene00006707
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables NEDD8 transferase activity. Involved in negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of nematode male tail tip morphogenesis; and protein neddylation. Predicted to be located in cytoplasm. Predicted to be part of HULC complex. Is expressed in hyp10. Orthologous to human UBE2F (ubiquitin conjugating enzyme E2 F (putative)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ubc-12 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_003279.8 (11911320..11912053)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R09B3.3 (e-PCR)
- UniSTS:320598

R09B3.4 (e-PCR)
- UniSTS:320744

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables NEDD8 conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables NEDD8 transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NEDD8 transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein neddylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein neddylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NEDD8-conjugating enzyme ubc-12

NP_493024.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

11911320..11912053

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060623.7 → NP_493024.1 NEDD8-conjugating enzyme ubc-12 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493024.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XVK5

Conserved Domains (1) summary

smart00212
Location:29 → 180

UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues