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mag-1 Protein mago nashi homolog [ Caenorhabditis elegans ]

Gene ID: 173073, updated on 2-Nov-2024

Summary

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Official Symbol
mag-1
Official Full Name
Protein mago nashi homolog
Primary source
WormBase:WBGene00003123
Locus tag
CELE_R09B3.5
See related
AllianceGenome:WB:WBGene00003123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including feminization of hermaphroditic germ-line; positive regulation of egg-laying behavior; and positive regulation of oogenesis. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome and exon-exon junction complex. Is expressed in head; pharynx; and tail. Orthologous to human MAGOHB (mago homolog B, exon junction complex subunit) and MAGOH (mago homolog, exon junction complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mag-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003279.8 (11912005..11912677, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene NEDD8-conjugating enzyme ubc-12 Neighboring gene Histone deacetylase Neighboring gene Farnesyl pyrophosphate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the Early Caenorhabditis elegans Embryo. Gauvin TJ, et al. G3 (Bethesda), 2018 Dec 10. PMID 30279189, Free PMC Article
  2. Ce-Y14 and MAG-1, components of the exon-exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans. Kawano T, et al. Mech Dev, 2004 Jan. PMID 14706697
  3. Studies on reproductive stress caused by candidate Gram positive and Gram negative bacteria using model organism, Caenorhabditis elegans. Sharika R, et al. Gene, 2018 Apr 5. PMID 29382573
  4. A specific set of exon junction complex subunits is required for the nuclear retention of unspliced RNAs in Caenorhabditis elegans. Shiimori M, et al. Mol Cell Biol, 2013 Jan. PMID 23149939, Free PMC Article
  5. The mago nashi locus encodes an essential product required for germ plasm assembly in Drosophila. Newmark PA, et al. Development, 1994 May. PMID 8026338

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in feminization of hermaphroditic germ-line IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear mRNA surveillance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exon-exon junction complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein mago nashi homolog
NP_493025.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    11912005..11912677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060624.9 → NP_493025.1  Protein mago nashi homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493025.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A023T4K3, O16104, O45714, P49029
    Conserved Domains (1) summary
    cd11295
    Location:10 → 152
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49029.2

Gene LinkOut

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