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pad-1 Protein pad-1 [ Caenorhabditis elegans ]

Gene ID: 173156, updated on 2-Nov-2024

Summary

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Official Symbol
pad-1
Official Full Name
Protein pad-1
Primary source
WormBase:WBGene00003905
Locus tag
CELE_Y18D10A.13
See related
AllianceGenome:WB:WBGene00003905
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in Golgi to endosome transport and protein transport. Predicted to be located in cytosol. Predicted to be active in endosome and trans-Golgi network. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; nervous system; and reproductive system. Used to study Down syndrome. Orthologous to human DOP1A (DOP1 leucine zipper like protein A) and DOP1B (DOP1 leucine zipper like protein B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pad-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
23
Sequence:
Chromosome: I; NC_003279.8 (12878639..12902806)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Amino acid transporter transmembrane domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Cytochrome c oxidase assembly factor 5 Neighboring gene Protein LSM14 homolog car-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conserved N- and C-terminal motifs of PAD-1 are required to inhibit extracellular vesicle release. Pitts LR, et al. MicroPubl Biol, 2022. PMID 36188098, Free PMC Article
  2. C21orf5, a novel human chromosome 21 gene, has a Caenorhabditis elegans ortholog (pad-1) required for embryonic patterning. Guipponi M, et al. Genomics, 2000 Aug 15. PMID 10950924
  3. Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. Pascon RC, et al. Mol Microbiol, 2000 Jun. PMID 10931277
  4. MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications. Artan M, et al. Autophagy, 2022 May. PMID 35188063, Free PMC Article
  5. Loss of the Major Phosphatidylserine or Phosphatidylethanolamine Flippases Differentially Affect Phagocytosis. Fazeli G, et al. Front Cell Dev Biol, 2020. PMID 32793595, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in Golgi to endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein pad-1
NP_493252.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12878639..12902806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060851.7 → NP_493252.3  Protein pad-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493252.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U5Z2, Q9XW10
    Conserved Domains (2) summary
    pfam04118
    Location:18 → 300
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2053 → 2373
    Dopey_N; Dopey, N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XW10.2

Gene LinkOut

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