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tba-2 Tubulin alpha-2 chain [ Caenorhabditis elegans ]

Gene ID: 173167, updated on 2-Nov-2024

Summary

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Official Symbol
tba-2
Official Full Name
Tubulin alpha-2 chain
Primary source
WormBase:WBGene00006529
Locus tag
CELE_C47B2.3
See related
AllianceGenome:WB:WBGene00006529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including centrosome localization; establishment of mitotic spindle orientation; and regulation of cytokinesis. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including body wall musculature; intestine; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human TUBA8 (tubulin alpha 8) and TUBAL3 (tubulin alpha like 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tba-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (12964674..12966271, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene Uracil phosphoribosyltransferase homolog Neighboring gene Proteasome subunit beta Neighboring gene Eukaryotic translation initiation factor 6 Neighboring gene UDP-glucose 4-epimerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective expression of the tba-1 alpha tubulin gene in a set of mechanosensory and motor neurons during the development of Caenorhabditis elegans. Fukushige T, et al. Biochim Biophys Acta, 1995 Apr 26. PMID 7742369
  2. The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth. Chaaban S, et al. Dev Cell, 2018 Oct 22. PMID 30245157
  3. Chronic exposure to methylmercury induces puncta formation in cephalic dopaminergic neurons in Caenorhabditis elegans. Ke T, et al. Neurotoxicology, 2020 Mar. PMID 31935438, Free PMC Article
  4. MEC-12, an alpha-tubulin required for touch sensitivity in C. elegans. Fukushige T, et al. J Cell Sci, 1999 Feb. PMID 9885292
  5. Mutations in a beta-tubulin disrupt spindle orientation and microtubule dynamics in the early Caenorhabditis elegans embryo. Wright AJ, et al. Mol Biol Cell, 2003 Nov. PMID 12937270, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tubulin alpha-2 chain
NP_001021050.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12964674..12966271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025879.7 → NP_001021050.1  Tubulin alpha-2 chain [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021050.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34690, Q95QR1
    UniProtKB/TrEMBL
    Q17409
    Conserved Domains (1) summary
    PTZ00335
    Location:1 → 437
    PTZ00335; tubulin alpha chain; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34690.1

Gene LinkOut

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