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Mid1 midline 1 [ Mus musculus (house mouse) ]

Gene ID: 17318, updated on 2-Nov-2024

Summary

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Official Symbol
Mid1provided by MGI
Official Full Name
midline 1provided by MGI
Primary source
MGI:MGI:1100537
See related
Ensembl:ENSMUSG00000035299 AllianceGenome:MGI:1100537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fxy; 61B3-R; Trim18; DXHXS1141
Summary
Predicted to enable several functions, including microtubule binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Located in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study Opitz GBBB syndrome and microphthalmia. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome. Orthologous to human MID1 (midline 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.3), cerebellum adult (RPKM 4.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Mid1 in Genome Data Viewer
Location:
X F5; X 79.19 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (168468178..168773692)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (169685199..169990798)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 15246 Neighboring gene STARR-seq mESC enhancer starr_48282 Neighboring gene predicted gene 15245 Neighboring gene STARR-seq mESC enhancer starr_48283 Neighboring gene predicted gene, 25651 Neighboring gene STARR-seq mESC enhancer starr_48284 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1B Neighboring gene predicted gene, 54065 Neighboring gene RIKEN cDNA G530011O06 gene Neighboring gene STARR-positive B cell enhancer mm9_chrX:166408204-166408505 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166407829-166408130 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166410801-166411102 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166413309-166413610 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166414802-166415103 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166415421-166415722 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166417053-166417354 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166417609-166417910 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166419073-166419374 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166420805-166421106 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166422120-166422421 Neighboring gene STARR-seq mESC enhancer starr_48290 Neighboring gene predicted gene 15247 Neighboring gene erythroid differentiation regulator 1 x Neighboring gene steroid sulfatase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A short pseudoautosomal region in laboratory mice. Perry J, et al. Genome Res, 2001 Nov. PMID 11691846, Free PMC Article
  2. Midline-1 regulates effector T cell motility in experimental autoimmune encephalomyelitis via mTOR/microtubule pathway. Wei Y, et al. Theranostics, 2024. PMID 38323310, Free PMC Article
  3. Midline 1 directs lytic granule exocytosis and cytotoxicity of mouse killer T cells. Boding L, et al. Eur J Immunol, 2014 Oct. PMID 25043946
  4. Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy. Ogura Y, et al. Cell Death Dis, 2022 Jul 13. PMID 35821212, Free PMC Article
  5. A gene spans the pseudoautosomal boundary in mice. Palmer S, et al. Proc Natl Acad Sci U S A, 1997 Oct 28. PMID 9342357, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification.
    Title: Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification.
  2. Midline-1 regulates effector T cell motility in experimental autoimmune encephalomyelitis via mTOR/microtubule pathway.
    Title: Midline-1 regulates effector T cell motility in experimental autoimmune encephalomyelitis via mTOR/microtubule pathway.
  3. Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
    Title: Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
  4. Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice.
    Title: Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice.
  5. E3 Ubiquitin Ligase Midline 1 Regulates Endothelial Cell ICAM-1 Expression and Neutrophil Adhesion in Abdominal Sepsis.
    Title: E3 Ubiquitin Ligase Midline 1 Regulates Endothelial Cell ICAM-1 Expression and Neutrophil Adhesion in Abdominal Sepsis.
  6. TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
    Title: TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
  7. Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy.
    Title: Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy.
  8. Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
    Title: Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
  9. lncRNA 5430416N02Rik Promotes the Proliferation of Mouse Embryonic Stem Cells by Activating Mid1 Expression through 3D Chromatin Architecture.
    Title: lncRNA 5430416N02Rik Promotes the Proliferation of Mouse Embryonic Stem Cells by Activating Mid1 Expression through 3D Chromatin Architecture.
  10. MID1 levels were inversely associated while PP2A activity levels correlated with DLco. Tnfsf10(-/-) and mice treated with the protein phosphatase 2A (PP2A) activator AAL(s) were largely protected against bleomycin-induced reductions in lung function and fibrotic changes. TRAIL signalling through MID1 deactivates PP2A and promotes fibrosis with corresponding lung function decline.
    Title: TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC60591

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of microtubule depolymerization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to microtubule IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Midline-1
Names
RING finger protein Midline-1
RING-type E3 ubiquitin transferase Midline-1
midin
tripartite motif-containing protein 18
NP_001277433.1
NP_001277434.1
NP_001277435.1
NP_001277441.1
NP_001412811.1
NP_001412812.1
NP_001412814.1
NP_001412815.1
NP_034927.2
XP_006528799.1
XP_006528800.1
XP_017173899.1
XP_017173900.1
XP_017173901.1
XP_017173902.1
XP_030107101.1
XP_030107103.1
XP_030107104.1
XP_036017723.1
XP_036017724.1
XP_036017725.1
XP_036017726.1
XP_036017727.1
XP_036017728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290504.2 → NP_001277433.1  E3 ubiquitin-protein ligase Midline-1 isoform 2

    See identical proteins and their annotated locations for NP_001277433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 3, 4, and 9 all encode the same isoform (2).
    Source sequence(s)
    AL672015, CR478112
    UniProtKB/Swiss-Prot
    O70583
    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:485 → 661
    SPRY; SPRY domain

  2. NM_001290505.2 → NP_001277434.1  E3 ubiquitin-protein ligase Midline-1 isoform 2

    See identical proteins and their annotated locations for NP_001277434.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 3, 4, and 9 all encode the same isoform (2).
    Source sequence(s)
    AL672015, CR478112
    UniProtKB/Swiss-Prot
    O70583
    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:485 → 661
    SPRY; SPRY domain

  3. NM_001290506.2 → NP_001277435.1  E3 ubiquitin-protein ligase Midline-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses two alternate in-frame splice sites, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL672015, CR478112
    UniProtKB/Swiss-Prot
    O70583
    Conserved Domains (6) summary
    smart00502
    Location:182 → 306
    BBC; B-Box C-terminal domain
    cd00063
    Location:357 → 443
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:285 → 336
    COS; TRIM C-terminal subgroup One Signature domain
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:447 → 623
    SPRY; SPRY domain

  4. NM_001290512.2 → NP_001277441.1  E3 ubiquitin-protein ligase Midline-1 isoform 4

    See identical proteins and their annotated locations for NP_001277441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate in-frame splice site, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL671865, AL672015, CR478112
    UniProtKB/TrEMBL
    B1AUZ9, Q3TVH5
    Related
    ENSMUSP00000107735.2, ENSMUST00000112107.8
    Conserved Domains (3) summary
    cd00063
    Location:189 → 275
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl02614
    Location:279 → 455
    SPRY; SPRY domain
    cl23765
    Location:17 → 138
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  5. NM_001425882.1 → NP_001412811.1  E3 ubiquitin-protein ligase Midline-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672015, CR478112
    UniProtKB/Swiss-Prot
    B1AV00, O35418, O70583, Q7TPT6

  6. NM_001425883.1 → NP_001412812.1  E3 ubiquitin-protein ligase Midline-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672015, CR478112
    UniProtKB/Swiss-Prot
    B1AV00, O35418, O70583, Q7TPT6
    Related
    ENSMUSP00000107733.2, ENSMUST00000112105.8

  7. NM_001425885.1 → NP_001412814.1  E3 ubiquitin-protein ligase Midline-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671865, AL672015, CR478112

  8. NM_001425886.1 → NP_001412815.1  E3 ubiquitin-protein ligase Midline-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672015, CR478112

  9. NM_010797.4 → NP_034927.2  E3 ubiquitin-protein ligase Midline-1 isoform 1

    See identical proteins and their annotated locations for NP_034927.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 7, and 8 all encode the same isoform (1).
    Source sequence(s)
    AL671865, AL672015, CR478112
    Consensus CDS
    CCDS41215.1
    UniProtKB/Swiss-Prot
    B1AV00, O35418, O70583, Q7TPT6
    Related
    ENSMUSP00000107732.2, ENSMUST00000112104.8
    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395 → 494
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:498 → 674
    SPRY; SPRY domain

RNA

  1. NR_189632.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672015, CR478112

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    168468178..168773692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161833.1 → XP_036017726.1  E3 ubiquitin-protein ligase Midline-1 isoform X7

    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00162
    Location:10 → 59
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:383 → 559
    SPRY; SPRY domain
    cl17238
    Location:8 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_036161832.1 → XP_036017725.1  E3 ubiquitin-protein ligase Midline-1 isoform X7

    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00162
    Location:10 → 59
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:383 → 559
    SPRY; SPRY domain
    cl17238
    Location:8 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_030251243.2 → XP_030107103.1  E3 ubiquitin-protein ligase Midline-1 isoform X5

    Conserved Domains (8) summary
    smart00502
    Location:191 → 308
    BBC; B-Box C-terminal domain
    cd00063
    Location:359 → 445
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:10 → 59
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam18568
    Location:287 → 338
    COS; TRIM C-terminal subgroup One Signature domain
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:449 → 625
    SPRY; SPRY domain
    cl17238
    Location:8 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  4. XM_030251244.2 → XP_030107104.1  E3 ubiquitin-protein ligase Midline-1 isoform X6

    Conserved Domains (6) summary
    smart00502
    Location:182 → 306
    BBC; B-Box C-terminal domain
    cd00063
    Location:357 → 443
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:285 → 336
    COS; TRIM C-terminal subgroup One Signature domain
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:447 → 623
    SPRY; SPRY domain

  5. XM_036161835.1 → XP_036017728.1  E3 ubiquitin-protein ligase Midline-1 isoform X9

    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395 → 494
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:10 → 59
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cl17238
    Location:8 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  6. XM_036161834.1 → XP_036017727.1  E3 ubiquitin-protein ligase Midline-1 isoform X8

    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:485 → 552
    SPRY; SPRY domain

  7. XM_036161831.1 → XP_036017724.1  E3 ubiquitin-protein ligase Midline-1 isoform X7

    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00162
    Location:10 → 59
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:383 → 559
    SPRY; SPRY domain
    cl17238
    Location:8 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  8. XM_017318411.3 → XP_017173900.1  E3 ubiquitin-protein ligase Midline-1 isoform X3

    Conserved Domains (8) summary
    smart00502
    Location:191 → 308
    BBC; B-Box C-terminal domain
    cd00063
    Location:359 → 458
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:10 → 59
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam18568
    Location:287 → 338
    COS; TRIM C-terminal subgroup One Signature domain
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:462 → 638
    SPRY; SPRY domain
    cl17238
    Location:8 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  9. XM_017318412.3 → XP_017173901.1  E3 ubiquitin-protein ligase Midline-1 isoform X4

    UniProtKB/TrEMBL
    B1AV01
    Related
    ENSMUSP00000077974.6, ENSMUST00000078947.12
    Conserved Domains (6) summary
    smart00502
    Location:182 → 306
    BBC; B-Box C-terminal domain
    cd00063
    Location:357 → 456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:285 → 336
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:460 → 636
    SPRY; SPRY domain

  10. XM_017318410.3 → XP_017173899.1  E3 ubiquitin-protein ligase Midline-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AV00, O35418, O70583, Q7TPT6
    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395 → 494
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:498 → 674
    SPRY; SPRY domain

  11. XM_036161830.1 → XP_036017723.1  E3 ubiquitin-protein ligase Midline-1 isoform X4

    UniProtKB/TrEMBL
    B1AV01
    Conserved Domains (6) summary
    smart00502
    Location:182 → 306
    BBC; B-Box C-terminal domain
    cd00063
    Location:357 → 456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:285 → 336
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:460 → 636
    SPRY; SPRY domain

  12. XM_030251241.2 → XP_030107101.1  E3 ubiquitin-protein ligase Midline-1 isoform X2

    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:485 → 661
    SPRY; SPRY domain

  13. XM_017318413.3 → XP_017173902.1  E3 ubiquitin-protein ligase Midline-1 isoform X13

    Conserved Domains (8) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:472 → 520
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:10 → 59
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:524 → 700
    SPRY; SPRY domain
    cl17238
    Location:8 → 61
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  14. XM_006528736.5 → XP_006528799.1  E3 ubiquitin-protein ligase Midline-1 isoform X10

    UniProtKB/TrEMBL
    B1AUZ9
    Conserved Domains (4) summary
    smart00502
    Location:24 → 77
    BBC; B-Box C-terminal domain
    cd00063
    Location:128 → 227
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18568
    Location:56 → 107
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:231 → 407
    SPRY; SPRY domain

  15. XM_006528737.5 → XP_006528800.1  E3 ubiquitin-protein ligase Midline-1 isoform X12

    See identical proteins and their annotated locations for XP_006528800.1

    UniProtKB/TrEMBL
    B1AUZ9, Q6PD02
    Related
    ENSMUSP00000078412.6, ENSMUST00000079443.6
    Conserved Domains (4) summary
    smart00502
    Location:24 → 77
    BBC; B-Box C-terminal domain
    cd00063
    Location:128 → 214
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18568
    Location:56 → 107
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:218 → 394
    SPRY; SPRY domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183151.1: Suppressed sequence

    Description
    NM_183151.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70583.2 GenPept UniProtKB/Swiss-Prot:O70583

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