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ola-1 Obg-like ATPase 1 [ Caenorhabditis elegans ]

Gene ID: 173205, updated on 2-Nov-2024

Summary

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Official Symbol
ola-1
Official Full Name
Obg-like ATPase 1
Primary source
WormBase:WBGene00012344
Locus tag
CELE_W08E3.3
See related
AllianceGenome:WB:WBGene00012344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP hydrolysis activity. Involved in behavioral response to starvation; thermosensory behavior; and thermotaxis. Located in endoplasmic reticulum. Is expressed in anal depressor muscle; hypodermis; intestine; nervous system; and pharyngeal muscle cell. Orthologous to human OLA1 (Obg like ATPase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ola-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (13340327..13343952)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene putative small nuclear ribonucleoprotein-associated protein B Neighboring gene WW domain-containing protein Neighboring gene WW domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans. Aoki I, et al. PLoS Genet, 2022 Jun. PMID 35675262, Free PMC Article
  2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal large subunit binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in behavioral response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thermosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thermotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 

General protein information

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Preferred Names
Obg-like ATPase 1
NP_001252138.1
  • Confirmed by transcript evidence
NP_001254006.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13340327..13343952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267077.3 → NP_001254006.1  Obg-like ATPase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254006.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E2JL06, P91917
    Conserved Domains (3) summary
    cd01900
    Location:24 → 300
    YchF; YchF GTPase
    PTZ00258
    Location:1 → 386
    PTZ00258; GTP-binding protein; Provisional
    pfam06071
    Location:302 → 385
    YchF-GTPase_C; Protein of unknown function (DUF933)

  2. NM_001265209.3 → NP_001252138.1  Obg-like ATPase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001252138.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2JL06
    Conserved Domains (1) summary
    PTZ00258
    Location:2 → 116
    PTZ00258; GTP-binding protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91917.1

Gene LinkOut

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