U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gpi-1 Glucose-6-phosphate isomerase [ Caenorhabditis elegans ]

Gene ID: 173227, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
gpi-1
Official Full Name
Glucose-6-phosphate isomerase
Primary source
WormBase:WBGene00013597
Locus tag
CELE_Y87G2A.8
See related
AllianceGenome:WB:WBGene00013597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to be active in cytosol. Is expressed in head; intestine; and nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See gpi-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (13576148..13581585)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ground-like domain-containing protein Neighboring gene PPIase cyclophilin-type domain-containing protein Neighboring gene Zc3h12a-like Ribonuclease NYN domain-containing protein Neighboring gene Ubiquitin-conjugating enzyme E2 S Neighboring gene Vacuolar protein sorting-associated protein 28 homolog

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Schulz TJ, et al. Cell Metab, 2007 Oct. PMID 17908557
  2. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
  3. Ageing and oxidants in the nematode Caenorhabditis elegans. Gems D. SEB Exp Biol Ser, 2009. PMID 19418991
  4. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article
  5. Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis. Lionaki E, et al. Nat Commun, 2022 Feb 3. PMID 35115503, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbohydrate derivative binding IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-6-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables monosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carbohydrate derivative metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Glucose-6-phosphate isomerase
NP_001021838.1
  • Confirmed by transcript evidence
NP_001370083.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13576148..13581585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026667.7 → NP_001021838.1  Glucose-6-phosphate isomerase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021838.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K707
    Conserved Domains (3) summary
    PRK00179
    Location:34 → 583
    pgi; glucose-6-phosphate isomerase; Reviewed
    cd05015
    Location:157 → 319
    SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...
    cd05016
    Location:367 → 558
    SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

  2. NM_001383747.2 → NP_001370083.1  Glucose-6-phosphate isomerase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1Q2
    Conserved Domains (1) summary
    PRK00179
    Location:1 → 548
    pgi; glucose-6-phosphate isomerase; Reviewed
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.