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sac-2 Inositol phosphatase domain-containing protein;SAC domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173236, updated on 2-Nov-2024

Summary

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Official Symbol
sac-2
Official Full Name
Inositol phosphatase domain-containing protein;SAC domain-containing protein
Primary source
WormBase:WBGene00012353
Locus tag
CELE_W09C5.7
See related
AllianceGenome:WB:WBGene00012353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-4-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and regulation of endocytic recycling. Predicted to be active in clathrin-coated endocytic vesicle and early endosome. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sac-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (13654009..13658167)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein eL31 Neighboring gene Cytochrome c oxidase subunit 4 Neighboring gene pseudo Neighboring gene Leucine Rich repeat-containing domain protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Yang S, et al. Neuron, 2022 Mar 2. PMID 35065714, Free PMC Article
  2. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. Zhang Z, et al. PLoS Genet, 2021 Feb. PMID 33524011, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in clathrin-coated endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Inositol phosphatase domain-containing protein;SAC domain-containing protein
NP_001252206.1
  • Confirmed by transcript evidence
NP_001252208.1
  • Confirmed by transcript evidence
NP_001364672.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13654009..13658167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001265277.2 → NP_001252206.1  SAC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001252206.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U330
    Conserved Domains (2) summary
    COG5329
    Location:25 → 520
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam12456
    Location:549 → 615
    hSac2; Inositol phosphatase

  2. NM_001377672.2 → NP_001364672.1  SAC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3W752
    Conserved Domains (2) summary
    COG5329
    Location:2 → 141
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam12456
    Location:170 → 236
    hSac2; Inositol phosphatase

  3. NM_001265279.3 → NP_001252208.1  Inositol phosphatase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001252208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3W753
    Conserved Domains (1) summary
    pfam12456
    Location:4 → 73
    hSac2; Inositol phosphatase
Nucleotide Protein
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