gpdh-1 Glycerol-3-phosphate dehydrogenase [NAD(+)] [Caenorhabditis elegans] - Gene

Summary

Official Symbol: gpdh-1
Official Full Name: Glycerol-3-phosphate dehydrogenase [NAD(+)]
Primary source: WormBase:WBGene00009824
Locus tag: CELE_F47G4.3
See related: AllianceGenome:WB:WBGene00009824
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in NADH oxidation and glycerol-3-phosphate metabolic process. Predicted to be part of glycerol-3-phosphate dehydrogenase (FAD) complex. Predicted to be active in cytosol. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Intestinal GPDH-1 regulates high glucose diet induced lifespan extension in aged worms.
Title: Intestinal GPDH-1 regulates high glucose diet induced lifespan extension in aged worms.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol-3-phosphate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of glycerol-3-phosphate dehydrogenase (FAD) complex	IEA Inferred from Electronic Annotation more info

NP_493454.1

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The following sections contain reference sequences that belong to a specific genome build. Explain