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pes-7 Calponin-homology (CH) domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173294, updated on 2-Nov-2024

Summary

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Official Symbol
pes-7
Official Full Name
Calponin-homology (CH) domain-containing protein
Primary source
WormBase:WBGene00003980
Locus tag
CELE_F09C3.1
See related
AllianceGenome:WB:WBGene00003980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in mitotic actomyosin contractile ring assembly actin filament organization. Predicted to be active in cell cortex. Is expressed in several structures, including hypodermis; intestine; nervous system; reproductive system; and tail. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1); IQGAP2 (IQ motif containing GTPase activating protein 2); and IQGAP3 (IQ motif containing GTPase activating protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pes-7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (14263297..14271321)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CW domain-containing protein Neighboring gene Secreted protein Neighboring gene Phosphoglycolate phosphatase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glia Promote Synaptogenesis through an IQGAP PES-7 in C. elegans. Dong X, et al. Cell Rep, 2020 Feb 25. PMID 32101740
  2. Molecular markers of differentiation in Caenorhabditis elegans obtained by promoter trapping. Young JM, et al. Dev Dyn, 1993 Feb. PMID 8364222
  3. Sticky worms: adhesion complexes in C. elegans. Cox EA, et al. J Cell Sci, 2004 Apr 15. PMID 15090594
  4. Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission. Locke CJ, et al. Genetics, 2009 Dec. PMID 19797046, Free PMC Article
  5. In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics. Lacroix B, et al. Dev Cell, 2014 Apr 28. PMID 24780738, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glia Promote Synaptogenesis through an IQGAP PES-7 in C. elegans.
    Title: Glia Promote Synaptogenesis through an IQGAP PES-7 in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Calponin-homology (CH) domain-containing protein
NP_493492.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14263297..14271321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061091.6 → NP_493492.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493492.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17772
    Conserved Domains (4) summary
    cd12206
    Location:790 → 1147
    RasGAP_IQGAP_related; Ras-GTPase Activating Domain of proteins related to IQGAPs
    pfam00307
    Location:46 → 157
    CH; Calponin homology (CH) domain
    pfam03836
    Location:1184 → 1313
    RasGAP_C; RasGAP C-terminus
    cl21455
    Location:363 → 474
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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