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hpo-13 Non-lysosomal glucosylceramidase [ Caenorhabditis elegans ]

Gene ID: 173305, updated on 18-Sep-2024

Summary

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Official Symbol
hpo-13
Official Full Name
Non-lysosomal glucosylceramidase
Primary source
WormBase:WBGene00013670
Locus tag
CELE_Y105E8A.10
See related
AllianceGenome:WB:WBGene00013670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process and glucosylceramide catabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See hpo-13 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (14418197..14431868)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene AP-1 complex subunit gamma Neighboring gene BolA-like protein 3 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables beta-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosylceramidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucosylceramide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Non-lysosomal glucosylceramidase
NP_001021681.1
  • Confirmed by transcript evidence
NP_001359639.1
  • Confirmed by transcript evidence
NP_001379302.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14418197..14431868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392976.1 → NP_001379302.1  Non-lysosomal glucosylceramidase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WQB2
    Conserved Domains (2) summary
    pfam04685
    Location:522 → 888
    DUF608; Glycosyl-hydrolase family 116, catalytic region
    pfam12215
    Location:149 → 457
    Glyco_hydr_116N; beta-glucosidase 2, glycosyl-hydrolase family 116 N-term

  2. NM_001373663.2 → NP_001359639.1  Non-lysosomal glucosylceramidase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6EUT3
    Conserved Domains (2) summary
    pfam04685
    Location:485 → 851
    DUF608; Glycosyl-hydrolase family 116, catalytic region
    pfam12215
    Location:112 → 415
    Glyco_hydr_116N; beta-glucosidase 2, glycosyl-hydrolase family 116 N-term

  3. NM_001026510.4 → NP_001021681.1  Non-lysosomal glucosylceramidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021681.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6EUT4
    Conserved Domains (2) summary
    pfam04685
    Location:493 → 861
    DUF608; Protein of unknown function, DUF608
    pfam12215
    Location:120 → 428
    GBA2_N; beta-Glucocerebrosidase 2 N terminal
Nucleotide Protein
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