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yars-1 Tyrosine--tRNA ligase [ Caenorhabditis elegans ]

Gene ID: 173311, updated on 18-Sep-2024

Summary

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Official Symbol
yars-1
Official Full Name
Tyrosine--tRNA ligase
Primary source
WormBase:WBGene00013677
Locus tag
CELE_Y105E8A.19
See related
AllianceGenome:WB:WBGene00013677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tyrosine-tRNA ligase activity. Predicted to be involved in tyrosyl-tRNA aminoacylation. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See yars-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (14476759..14486767, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS10 Neighboring gene SANT_DAMP1_like domain-containing protein Neighboring gene Methionine--tRNA ligase, mitochondrial Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  2. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  3. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tyrosine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tyrosine--tRNA ligase
NP_740947.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14476759..14486767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170951.6 → NP_740947.2  Tyrosine--tRNA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740947.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED95
    Conserved Domains (2) summary
    TIGR00233
    Location:45 → 359
    trpS; tryptophanyl-tRNA synthetase
    cl00015
    Location:21 → 330
    nt_trans; nucleotidyl transferase superfamily
Nucleotide Protein
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