U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Y105E8A.20 Methionine--tRNA ligase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 173312, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Y105E8A.20
Official Full Name
Methionine--tRNA ligase, mitochondrial
Primary source
WormBase:WBGene00013678
Locus tag
CELE_Y105E8A.20
See related
AllianceGenome:WB:WBGene00013678
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Y105E8A.20 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (14486877..14496560, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS10 Neighboring gene SANT_DAMP1_like domain-containing protein Neighboring gene Tyrosine--tRNA ligase Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein;TFIIIC_sub6 domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables methionine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methionyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Methionine--tRNA ligase, mitochondrial
NP_001129797.1
  • Confirmed by transcript evidence
NP_740948.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14486877..14496560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170952.5 → NP_740948.2  Methionine--tRNA ligase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740948.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z260, Q8WQA1
    Conserved Domains (1) summary
    PRK11893
    Location:2 → 401
    PRK11893; methionyl-tRNA synthetase; Reviewed

  2. NM_001136325.3 → NP_001129797.1  Methionine--tRNA ligase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129797.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3KYC0, Q7Z260
    Conserved Domains (1) summary
    PRK11893
    Location:12 → 519
    PRK11893; methionyl-tRNA synthetase; Reviewed
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools