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exc-4 Chloride intracellular channel exc-4 [ Caenorhabditis elegans ]

Gene ID: 173314, updated on 2-Nov-2024

Summary

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Official Symbol
exc-4
Official Full Name
Chloride intracellular channel exc-4
Primary source
WormBase:WBGene00001365
Locus tag
CELE_Y105E8A.22
See related
AllianceGenome:WB:WBGene00001365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chloride channel activity. Involved in epithelial cell development and regulation of tube size. Located in apical junction complex; apical plasma membrane; and lysosome. Is expressed in several structures, including amphid sheath cell; excretory system; pharyngeal muscle cell; rectum; and vulva. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 103. Orthologous to several human genes including CLIC2 (chloride intracellular channel 2) and CLIC4 (chloride intracellular channel 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See exc-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (14511431..14518719, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein;TFIIIC_sub6 domain-containing protein Neighboring gene ncRNA Neighboring gene Tight junction protein ZO-1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A metazoan-specific C-terminal motif in EXC-4 and Gα-Rho/Rac signaling regulate cell outgrowth during tubulogenesis in C. elegans. Arena AF, et al. Development, 2022 Dec 15. PMID 36398726, Free PMC Article
  2. Chloride intracellular channel (CLIC) proteins function as fusogens. Manori B, et al. Nat Commun, 2024 Mar 7. PMID 38453905, Free PMC Article
  3. A C. elegans CLIC-like protein required for intracellular tube formation and maintenance. Berry KL, et al. Science, 2003 Dec 19. PMID 14684823
  4. Mapping functional domains of chloride intracellular channel (CLIC) proteins in vivo. Berry KL, et al. J Mol Biol, 2006 Jun 23. PMID 16737711
  5. Comparison of vertebrate and invertebrate CLIC proteins: the crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC. Littler DR, et al. Proteins, 2008 Apr. PMID 17985355

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. distinguishing features of exc-4 structure determined from crystal structure are described
    Title: Comparison of vertebrate and invertebrate CLIC proteins: the crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC.
  2. The putative transmembrane (PTM) region thus provides both targeting information and Chloride intracellular channel functional specificity, possibly adapting GST-type proteins to function as ion channels.
    Title: Mapping functional domains of chloride intracellular channel (CLIC) proteins in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of tube size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical junction complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Chloride intracellular channel exc-4
NP_740950.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14511431..14518719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170954.3 → NP_740950.2  Chloride intracellular channel exc-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740950.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8WQA4
    Conserved Domains (3) summary
    TIGR00862
    Location:17 → 243
    O-ClC; intracellular chloride channel protein
    cd03198
    Location:115 → 248
    GST_C_CLIC; C-terminal, alpha helical domain of Chloride Intracellular Channels
    cd03061
    Location:14 → 109
    GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WQA4.2

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