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lev-11 Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e [ Caenorhabditis elegans ]

Gene ID: 173319, updated on 2-Nov-2024

Summary

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Official Symbol
lev-11
Official Full Name
Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e
Primary source
WormBase:WBGene00002978
Locus tag
CELE_Y105E8B.1
See related
AllianceGenome:WB:WBGene00002978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Is expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in blood platelet disease; congenital myopathy (multiple); distal arthrogryposis type 1A; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lev-11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
16
Sequence:
Chromosome: I; NC_003279.8 (14621169..14631094, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DH domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acyl-CoA dehydrogenase Neighboring gene ncRNA Neighboring gene Exocyst component Exo84 C-terminal domain-containing protein;PH domain-containing protein Neighboring gene Protein AF-9 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative splicing of a single exon causes a major impact on the affinity of Caenorhabditis elegans tropomyosin isoforms for actin filaments. Ono S, et al. Front Cell Dev Biol, 2023. PMID 37745299, Free PMC Article
  2. Genome structure, mapping and expression of the tropomyosin gene tmy-1 of Caenorhabditis elegans. Kagawa H, et al. J Mol Biol, 1995 Sep 1. PMID 7666414
  3. Alternative splicing of the Caenorhabditis elegans lev-11 tropomyosin gene is regulated in a tissue-specific manner. Watabe E, et al. Cytoskeleton (Hoboken), 2018 Oct. PMID 30155988, Free PMC Article
  4. Mutual dependence between tropomodulin and tropomyosin in the regulation of sarcomeric actin assembly in Caenorhabditis elegans striated muscle. Ono S, et al. Eur J Cell Biol, 2022 Apr. PMID 35306452, Free PMC Article
  5. The third and fourth tropomyosin isoforms of Caenorhabditis elegans are expressed in the pharynx and intestines and are essential for development and morphology. Anyanful A, et al. J Mol Biol, 2001 Oct 26. PMID 11676537

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results present models by which ELT-2, PHA-4, and CdxA orchestrate expression from the internal promoter of tmy-1/lev-11.
    Title: Transcription factors GATA/ELT-2 and forkhead/HNF-3/PHA-4 regulate the tropomyosin gene expression in the pharynx and intestine of Caenorhabditis elegans.
  2. Troponin C and tropomyosin are the actin-linked regulators for contraction of ovarian muscle in the C. elegans reproductive system.
    Title: Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spicule insertion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in I band IEA
Inferred from Electronic Annotation
more info
  
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e
NP_001021695.1
  • Confirmed by transcript evidence
NP_001021697.1
  • Confirmed by transcript evidence
NP_001300453.1
  • Confirmed by transcript evidence
NP_001300454.1
  • Confirmed by transcript evidence
NP_001300455.1
  • Confirmed by transcript evidence
NP_001300456.1
  • Confirmed by transcript evidence
NP_001300457.1
  • Confirmed by transcript evidence
NP_001300458.1
  • Partially confirmed by transcript evidence
NP_001300459.1
  • Partially confirmed by transcript evidence
NP_001300460.1
  • Confirmed by transcript evidence
NP_001300461.1
  • Partially confirmed by transcript evidence
NP_001367007.1
  • Partially confirmed by transcript evidence
NP_001367087.1
  • Confirmed by transcript evidence
NP_001368154.1
  • Partially confirmed by transcript evidence
NP_001368155.1
  • Partially confirmed by transcript evidence
NP_001368156.1
  • Partially confirmed by transcript evidence
NP_001370127.1
  • Confirmed by transcript evidence
NP_001370969.1
  • Confirmed by transcript evidence
NP_001379312.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14621169..14631094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381266.2 → NP_001367087.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam12718
    Location:7 → 112
    Tropomyosin_1; Tropomyosin like

  2. NM_001313528.5 → NP_001300457.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWP0
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin

  3. NM_001313525.5 → NP_001300454.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATR6
    Conserved Domains (2) summary
    pfam00261
    Location:20 → 254
    Tropomyosin; Tropomyosin
    pfam01496
    Location:112 → 180
    V_ATPase_I; V-type ATPase 116kDa subunit family

  4. NM_001026526.7 → NP_001021697.1  Tropomyosin isoforms c/e [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021697.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27249
    Conserved Domains (2) summary
    pfam00261
    Location:20 → 254
    Tropomyosin; Tropomyosin
    pfam01496
    Location:112 → 180
    V_ATPase_I; V-type ATPase 116kDa subunit family

  5. NM_001392977.1 → NP_001379312.1  Tropomyosin isoforms c/e [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27249, Q9GSR4
    Conserved Domains (1) summary
    pfam00261
    Location:20 → 254
    Tropomyosin

  6. NM_001381263.2 → NP_001367007.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam00261
    Location:16 → 191
    Tropomyosin

  7. NM_001383761.2 → NP_001370127.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  8. NM_001383762.2 → NP_001370969.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1Q2U2F4
    Conserved Domains (1) summary
    pfam00261
    Location:20 → 254
    Tropomyosin

  9. NM_001313524.3 → NP_001300453.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARB5
    Conserved Domains (1) summary
    pfam00261
    Location:20 → 254
    Tropomyosin; Tropomyosin

  10. NM_001026524.8 → NP_001021695.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021695.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22865, Q22866, Q27284, Q7K6W7, Q95Q31
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin

  11. NM_001313531.4 → NP_001300460.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQT4
    Conserved Domains (3) summary
    COG4985
    Location:2 → 80
    COG4985; ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin
    pfam01496
    Location:140 → 208
    V_ATPase_I; V-type ATPase 116kDa subunit family

  12. NM_001313529.3 → NP_001300458.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARC0
    Conserved Domains (3) summary
    COG4985
    Location:2 → 80
    COG4985; ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin
    pfam01496
    Location:140 → 225
    V_ATPase_I; V-type ATPase 116kDa subunit family

  13. NM_001313532.5 → NP_001300461.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUC2
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin

  14. NM_001313530.3 → NP_001300459.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATS1
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin

  15. NM_001313526.3 → NP_001300455.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQS9
    Conserved Domains (1) summary
    pfam00261
    Location:16 → 191
    Tropomyosin; Tropomyosin

  16. NM_001313527.3 → NP_001300456.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUC0
    Conserved Domains (1) summary
    pfam00261
    Location:1 → 153
    Tropomyosin; Tropomyosin

  17. NM_001381261.2 → NP_001368155.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8FDX2
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  18. NM_001381264.1 → NP_001368156.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ESC3
    Conserved Domains (1) summary
    pfam00261
    Location:16 → 191
    Tropomyosin

  19. NM_001381265.1 → NP_001368154.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ERM4
    Conserved Domains (1) summary
    pfam00261
    Location:1 → 153
    Tropomyosin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22866.1
Q27249.1

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