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lev-11 Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e [ Caenorhabditis elegans ]

Gene ID: 173319, updated on 2-Nov-2024

Summary

Official Symbol
lev-11
Official Full Name
Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e
Primary source
WormBase:WBGene00002978
Locus tag
CELE_Y105E8B.1
See related
AllianceGenome:WB:WBGene00002978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Is expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in blood platelet disease; congenital myopathy (multiple); distal arthrogryposis type 1A; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See lev-11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
16
Sequence:
Chromosome: I; NC_003279.8 (14621169..14631094, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DH domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acyl-CoA dehydrogenase Neighboring gene ncRNA Neighboring gene Exocyst component Exo84 C-terminal domain-containing protein;PH domain-containing protein Neighboring gene Protein AF-9 homolog

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in I band IEA
Inferred from Electronic Annotation
more info
 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e
NP_001021695.1
  • Confirmed by transcript evidence
NP_001021697.1
  • Confirmed by transcript evidence
NP_001300453.1
  • Confirmed by transcript evidence
NP_001300454.1
  • Confirmed by transcript evidence
NP_001300455.1
  • Confirmed by transcript evidence
NP_001300456.1
  • Confirmed by transcript evidence
NP_001300457.1
  • Confirmed by transcript evidence
NP_001300458.1
  • Partially confirmed by transcript evidence
NP_001300459.1
  • Partially confirmed by transcript evidence
NP_001300460.1
  • Confirmed by transcript evidence
NP_001300461.1
  • Partially confirmed by transcript evidence
NP_001367007.1
  • Partially confirmed by transcript evidence
NP_001367087.1
  • Confirmed by transcript evidence
NP_001368154.1
  • Partially confirmed by transcript evidence
NP_001368155.1
  • Partially confirmed by transcript evidence
NP_001368156.1
  • Partially confirmed by transcript evidence
NP_001370127.1
  • Confirmed by transcript evidence
NP_001370969.1
  • Confirmed by transcript evidence
NP_001379312.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14621169..14631094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381266.2NP_001367087.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam12718
    Location:7112
    Tropomyosin_1; Tropomyosin like
  2. NM_001313528.5NP_001300457.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWP0
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  3. NM_001313525.5NP_001300454.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATR6
    Conserved Domains (2) summary
    pfam00261
    Location:20254
    Tropomyosin; Tropomyosin
    pfam01496
    Location:112180
    V_ATPase_I; V-type ATPase 116kDa subunit family
  4. NM_001026526.7NP_001021697.1  Tropomyosin isoforms c/e [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021697.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27249
    Conserved Domains (2) summary
    pfam00261
    Location:20254
    Tropomyosin; Tropomyosin
    pfam01496
    Location:112180
    V_ATPase_I; V-type ATPase 116kDa subunit family
  5. NM_001392977.1NP_001379312.1  Tropomyosin isoforms c/e [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27249, Q9GSR4
    Conserved Domains (1) summary
    pfam00261
    Location:20254
    Tropomyosin
  6. NM_001381263.2NP_001367007.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam00261
    Location:16191
    Tropomyosin
  7. NM_001383761.2NP_001370127.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  8. NM_001383762.2NP_001370969.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1Q2U2F4
    Conserved Domains (1) summary
    pfam00261
    Location:20254
    Tropomyosin
  9. NM_001313524.3NP_001300453.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARB5
    Conserved Domains (1) summary
    pfam00261
    Location:20254
    Tropomyosin; Tropomyosin
  10. NM_001026524.8NP_001021695.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021695.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22865, Q22866, Q27284, Q7K6W7, Q95Q31
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  11. NM_001313531.4NP_001300460.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQT4
    Conserved Domains (3) summary
    COG4985
    Location:280
    COG4985; ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
    pfam01496
    Location:140208
    V_ATPase_I; V-type ATPase 116kDa subunit family
  12. NM_001313529.3NP_001300458.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARC0
    Conserved Domains (3) summary
    COG4985
    Location:280
    COG4985; ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
    pfam01496
    Location:140225
    V_ATPase_I; V-type ATPase 116kDa subunit family
  13. NM_001313532.5NP_001300461.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUC2
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  14. NM_001313530.3NP_001300459.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATS1
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin; Tropomyosin
  15. NM_001313526.3NP_001300455.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQS9
    Conserved Domains (1) summary
    pfam00261
    Location:16191
    Tropomyosin; Tropomyosin
  16. NM_001313527.3NP_001300456.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUC0
    Conserved Domains (1) summary
    pfam00261
    Location:1153
    Tropomyosin; Tropomyosin
  17. NM_001381261.2NP_001368155.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8FDX2
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  18. NM_001381264.1NP_001368156.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ESC3
    Conserved Domains (1) summary
    pfam00261
    Location:16191
    Tropomyosin
  19. NM_001381265.1NP_001368154.1  Tropomyosin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ERM4
    Conserved Domains (1) summary
    pfam00261
    Location:1153
    Tropomyosin