exoc-8 Exocyst component Exo84 C-terminal domain-containing protein;PH domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: exoc-8
Official Full Name: Exocyst component Exo84 C-terminal domain-containing protein;PH domain-containing protein
Primary source: WormBase:WBGene00013687
Locus tag: CELE_Y105E8B.2
See related: AllianceGenome:WB:WBGene00013687
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in Golgi to plasma membrane transport and protein localization. Predicted to be part of exocyst. Is expressed in PVDL and PVDR. Orthologous to human EXOC8 (exocyst complex component 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See exoc-8 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (14634453..14642568, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings identify novel, potential regulators for exocyst function and show that exoc-7 and exoc-8 are functionally linked to rab-10 in endosomal trafficking in intestinal epithelial cells in C. elegans.
Title: Exocyst subunits Exo70 and Exo84 cooperate with small GTPases to regulate behavior and endocytic trafficking in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-224 (e-PCR)
- UniSTS:241718

Y105E8A.b (e-PCR)
- UniSTS:323829

Y105E8A.c (e-PCR)
- UniSTS:323830

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IEA Inferred from Electronic Annotation more info
part_of exocyst	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Exocyst component Exo84 C-terminal domain-containing protein;PH domain-containing protein

NP_001021702.1

Confirmed by transcript evidence

NP_001359664.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14634453..14642568 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026531.6 → NP_001021702.1 Exocyst component Exo84 C-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021702.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95Q35

Conserved Domains (3) summary

pfam08700
Location:9 → 98

Vps51; Vps51/Vps67

pfam16528
Location:306 → 467

Exo84_C; Exocyst component 84 C-terminal

cl17171
Location:140 → 252

PH-like; Pleckstrin homology-like domain
NM_001373669.4 → NP_001359664.1 PH domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7YTV2

Conserved Domains (2) summary

pfam08700
Location:9 → 98

Vps51; Vps51/Vps67

cl17171
Location:140 → 252

PH-like; Pleckstrin homology-like domain