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riok-2 Serine/threonine-protein kinase RIO2 [ Caenorhabditis elegans ]

Gene ID: 173322, updated on 2-Nov-2024

Summary

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Official Symbol
riok-2
Official Full Name
Serine/threonine-protein kinase RIO2
Primary source
WormBase:WBGene00013688
Locus tag
CELE_Y105E8B.3
See related
AllianceGenome:WB:WBGene00013688
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein kinase activity. Involved in nematode larval development. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol and nucleus. Orthologous to human RIOK2 (RIO kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See riok-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (14652116..14657275)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein AF-9 homolog Neighboring gene BTB and MATH domain-containing protein 40 Neighboring gene Hypoxanthine phosphoribosyltransferase Neighboring gene ncRNA Neighboring gene BZIP domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Flatworms have lost the right open reading frame kinase 3 gene during evolution. Breugelmans B, et al. Sci Rep, 2015 May 15. PMID 25976756, Free PMC Article
  2. Bioinformatic exploration of RIO protein kinases of parasitic and free-living nematodes. Breugelmans B, et al. Int J Parasitol, 2014 Oct 1. PMID 25038443
  3. Atypical (RIO) protein kinases from Haemonchus contortus--promise as new targets for nematocidal drugs. Campbell BE, et al. Biotechnol Adv, 2011 May-Jun. PMID 21262337
  4. Investigating the role of RIO protein kinases in Caenorhabditis elegans. Mendes TK, et al. PLoS One, 2015. PMID 25688864, Free PMC Article
  5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serine/threonine-protein kinase RIO2
NP_493544.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14652116..14657275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061143.9 → NP_493544.2  Serine/threonine-protein kinase RIO2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493544.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95Q34
    Conserved Domains (3) summary
    COG0478
    Location:6 → 314
    RIO2; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]
    cd05144
    Location:94 → 276
    RIO2_C; C-terminal catalytic domain of the atypical protein serine kinase, RIO2 kinase
    pfam09202
    Location:9 → 91
    Rio2_N; Rio2, N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95Q34.2

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