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Y105E8B.9 Beta-glucuronidase [ Caenorhabditis elegans ]

Gene ID: 173326, updated on 2-Nov-2024

Summary

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Official Symbol
Y105E8B.9
Official Full Name
Beta-glucuronidase
Primary source
WormBase:WBGene00013693
Locus tag
CELE_Y105E8B.9
See related
AllianceGenome:WB:WBGene00013693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable beta-glucuronidase activity and carbohydrate binding activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in lysosome. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y105E8B.9 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (14675600..14682566, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene BZIP domain-containing protein Neighboring gene Endoplasmic oxidoreductin;Endoplasmic reticulum oxidoreductin-1 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Putative sphingolipid delta(4)-desaturase/C4-monooxygenase Neighboring gene Recep_L_domain domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables beta-glucuronidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-glucuronidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Beta-glucuronidase
NP_493548.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14675600..14682566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061147.6 → NP_493548.1  Beta-glucuronidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493548.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Q32
    Conserved Domains (4) summary
    PRK10150
    Location:22 → 615
    PRK10150; beta-D-glucuronidase; Provisional
    pfam00703
    Location:224 → 317
    Glyco_hydro_2; Glycosyl hydrolases family 2
    pfam02837
    Location:31 → 222
    Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
    cl23725
    Location:323 → 615
    Glyco_hydro_1; Glycosyl hydrolase family 1
Nucleotide Protein
Heading Accession and Version

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