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dus-2 DRBM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173331, updated on 2-Nov-2024

Summary

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Official Symbol
dus-2
Official Full Name
DRBM domain-containing protein
Primary source
WormBase:WBGene00013201
Locus tag
CELE_Y54E5A.6
See related
AllianceGenome:WB:WBGene00013201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Predicted to be active in cytoplasm. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dus-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (14708231..14718511, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nucleoporin p58/p45 Neighboring gene Polysaccharide biosynthesis domain-containing protein Neighboring gene B30.2/SPRY domain-containing protein;CTLH domain-containing protein Neighboring gene Conserved plasma membrane protein;Pyridoxamine 5'-phosphate oxidase;Uncharacterized protein Neighboring gene Proteasome subunit pbs-5 Neighboring gene Protein jagunal homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA dihydrouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DRBM domain-containing protein
NP_493554.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14708231..14718511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061153.4 → NP_493554.1  DRBM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493554.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XWJ9
    Conserved Domains (2) summary
    cd02801
    Location:8 → 248
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cl00054
    Location:359 → 425
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
Nucleotide Protein
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