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K05C4.5 [ Caenorhabditis elegans ]

Gene ID: 173339, updated on 22-Aug-2024

Summary

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Official Symbol
K05C4.5
Primary source
WormBase:WBGene00010582
Locus tag
CELE_K05C4.5
See related
AllianceGenome:WB:WBGene00010582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of 90S preribosome; small-subunit processome; and t-UTP complex. Human ortholog(s) of this gene implicated in cholestasis and primary biliary cholangitis. Orthologous to human UTP4 (UTP4 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (14742765..14747789)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Armadillo repeat-containing protein 1 Neighboring gene Armadillo/beta-catenin-like repeat protein;Beta-catenin-like protein hmp-2 Neighboring gene F-box/LRR-repeat protein Neighboring gene Metaxin-1 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans in the study of SMN-interacting proteins: a role for SMI-1, an orthologue of human Gemin2 and the identification of novel components of the SMN complex. Burt EC, et al. Invert Neurosci, 2006 Dec. PMID 16964508
  2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of t-UTP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD_REPEATS_REGION domain-containing protein
NP_493567.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14742765..14747789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061166.5 → NP_493567.2  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493567.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUU8
    Conserved Domains (1) summary
    COG2319
    Location:59 → 297
    WD40; WD40 repeat [General function prediction only]
Nucleotide Protein
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