smp-1 Sema domain-containing protein;Semaphorin-1A [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: smp-1
Official Full Name: Sema domain-containing protein;Semaphorin-1A
Primary source: WormBase:WBGene00004889
Locus tag: CELE_Y54E5B.1
See related: AllianceGenome:WB:WBGene00004889
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables semaphorin receptor binding activity. Involved in nematode male tail mating organ morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including hermaphrodite distal tip cell; male-specific anatomical entity; non-striated muscle; somatic nervous system; and vulval cell. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia and progressive myoclonus epilepsy. Orthologous to several human genes including SEMA3B (semaphorin 3B); SEMA3C (semaphorin 3C); and SEMA6A (semaphorin 6A). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See smp-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (14807462..14815729)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Semaphorin-1 and netrin signal in parallel and permissively to position the male ray 1 sensillum in Caenorhabditis elegans.
Title: Semaphorin-1 and netrin signal in parallel and permissively to position the male ray 1 sensillum in Caenorhabditis elegans.
Data show genetically that plexin-1 is part of the same functional pathway as semaphorin-1 and -2 for C. elegans male ray cell positioning.
Title: Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

STS1-226 (e-PCR)
- UniSTS:241720

Y54E5B.1 (e-PCR)
- UniSTS:313340

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode male tail mating organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode male tail mating organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Sema domain-containing protein;Semaphorin-1A

NP_001370129.1

Confirmed by transcript evidence

NP_001391076.1

Confirmed by transcript evidence

NP_493582.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14807462..14815729

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001404220.1 → NP_001391076.1 Sema domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A7R9SVH9
NM_001383767.1 → NP_001370129.1 Sema domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95Q16

Conserved Domains (1) summary

cl15693
Location:49 → 247

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
NM_061181.8 → NP_493582.3 Semaphorin-1A [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493582.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17330, Q9XWF8

Conserved Domains (2) summary

cd11237
Location:49 → 497

Sema_1A; The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)

smart00423
Location:496 → 547

PSI; domain found in Plexins, Semaphorins and Integrins