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tep-1 TEP (ThiolEster containing Protein) [ Caenorhabditis elegans ]

Gene ID: 173367, updated on 2-Nov-2024

Summary

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Official Symbol
tep-1
Official Full Name
TEP (ThiolEster containing Protein)
Primary source
WormBase:WBGene00013969
Locus tag
CELE_ZK337.1
See related
AllianceGenome:WB:WBGene00013969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable endopeptidase inhibitor activity. Predicted to be located in extracellular space. Is expressed in hypodermis; nervous system; and reproductive system. Orthologous to human CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tep-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
18
Sequence:
Chromosome: I; NC_003279.8 (14994581..15001691)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DBD_Tnp_Mut domain-containing protein Neighboring gene pseudo Neighboring gene Protein mtd-1 Neighboring gene DNA polymerase epsilon catalytic subunit Neighboring gene Regulator of microtubule dynamics protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A large repertoire of parasite epitopes matched by a large repertoire of host immune receptors in an invertebrate host/parasite model. Moné Y, et al. PLoS Negl Trop Dis, 2010 Sep 7. PMID 20838648, Free PMC Article
  2. C. elegans BLMP-1 controls apical epidermal cell morphology by repressing expression of mannosyltransferase bus-8 and molting signal mlt-8. Wu YZ, et al. Dev Biol, 2022 Jun. PMID 35367457
  3. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
  4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TEP (ThiolEster containing Protein)
NP_001366904.1
  • Product from WormBase gene class tep;
    Confirmed by transcript evidence
NP_001367060.1
  • Product from WormBase gene class tep;
    Confirmed by transcript evidence
NP_001379225.1
  • Product from WormBase gene class tep;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14994581..15001691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392981.1 → NP_001379225.1  TEP (ThiolEster containing Protein) [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JKM0
    Conserved Domains (5) summary
    COG2373
    Location:100 → 1308
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:970 → 1261
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:750 → 840
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:1365 → 1454
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:495 → 631
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

  2. NM_001381277.1 → NP_001367060.1  TEP (ThiolEster containing Protein) [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YTU0
    Conserved Domains (5) summary
    COG2373
    Location:100 → 1316
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:978 → 1269
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:758 → 848
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:1373 → 1462
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:495 → 631
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

  3. NM_001381276.2 → NP_001366904.1  TEP (ThiolEster containing Protein) [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46014, O46015
    Conserved Domains (5) summary
    COG2373
    Location:100 → 1319
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:981 → 1272
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:761 → 851
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:1376 → 1465
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:495 → 631
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
Nucleotide Protein
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