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etr-1 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173401, updated on 2-Nov-2024

Summary

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Official Symbol
etr-1
Official Full Name
RRM domain-containing protein
Primary source
WormBase:WBGene00001340
Locus tag
CELE_T01D1.2
See related
AllianceGenome:WB:WBGene00001340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA 3'-UTR binding activity. Involved in determination of adult lifespan. Located in nucleus. Is expressed in body wall musculature; copulatory spicule; germ line; muscle cell; and somatic gonad. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to several human genes including CELF1 (CUGBP Elav-like family member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See etr-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
14
Sequence:
Chromosome: II; NC_003280.10 (162423..170631)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine receptor class gamma Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans ETR-1/CELF has broad effects on the muscle cell transcriptome, including genes that regulate translation and neuroblast migration. Ochs ME, et al. BMC Genomics, 2022 Jan 6. PMID 34986795, Free PMC Article
  2. The Predicted RNA-Binding Protein ETR-1/CELF1 Acts in Muscles To Regulate Neuroblast Migration in Caenorhabditis elegans. Ochs ME, et al. G3 (Bethesda), 2020 Jul 7. PMID 32398235, Free PMC Article
  3. ETR-1, a homologue of a protein linked to myotonic dystrophy, is essential for muscle development in Caenorhabditis elegans. Milne CA, et al. Curr Biol, 1999 Nov 4. PMID 10556089
  4. Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses. Boateng R, et al. Dev Biol, 2017 Sep 1. PMID 28648844, Free PMC Article
  5. Growth-dependent effect of muscleblind knockdown on Caenorhabditis elegans. Wang LC, et al. Biochem Biophys Res Commun, 2008 Feb 15. PMID 18082131

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this data identifies a novel role for ETR-1 in hermaphrodite gametogenesis and in the process of engulfment of germline apoptotic cell corpses.
    Title: Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_001367867.1
  • Confirmed by transcript evidence
NP_001367869.1
  • Confirmed by transcript evidence
NP_001367870.1
  • Confirmed by transcript evidence
NP_001367871.1
  • Confirmed by transcript evidence
NP_001368521.1
  • Confirmed by transcript evidence
NP_001368522.1
  • Confirmed by transcript evidence
NP_001368523.1
  • Confirmed by transcript evidence
NP_001368524.1
  • Confirmed by transcript evidence
NP_001368525.1
  • Confirmed by transcript evidence
NP_001368526.1
  • Confirmed by transcript evidence
NP_001368527.1
  • Confirmed by transcript evidence
NP_001368528.1
  • Confirmed by transcript evidence
NP_001368529.1
  • Confirmed by transcript evidence
NP_001368530.1
  • Confirmed by transcript evidence
NP_001368531.1
  • Confirmed by transcript evidence
NP_001368532.1
  • Confirmed by transcript evidence
NP_001368533.1
  • Confirmed by transcript evidence
NP_001370740.1
  • Confirmed by transcript evidence
NP_001379970.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    162423..170631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381293.1 → NP_001367870.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYS1
    Conserved Domains (4) summary
    TIGR01628
    Location:57 → 580
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12362
    Location:503 → 575
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:141 → 221
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  2. NM_001381292.3 → NP_001367871.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYS0
    Conserved Domains (4) summary
    TIGR01628
    Location:57 → 582
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12362
    Location:505 → 577
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:141 → 221
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  3. NM_001392986.1 → NP_001379970.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7KQE9
    Conserved Domains (3) summary
    cd12362
    Location:430 → 502
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:141 → 221
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  4. NM_001381290.3 → NP_001367867.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF03
    Conserved Domains (3) summary
    cd12362
    Location:501 → 573
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:141 → 221
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  5. NM_001381291.1 → NP_001368521.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUP0
    Conserved Domains (4) summary
    TIGR01628
    Location:57 → 583
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12362
    Location:506 → 578
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:141 → 221
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  6. NM_001383771.1 → NP_001370740.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYS3
    Conserved Domains (4) summary
    TIGR01628
    Location:57 → 529
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12362
    Location:452 → 524
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cl17169
    Location:141 → 209
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. NM_001381296.1 → NP_001368522.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AX05
    Conserved Domains (3) summary
    TIGR01661
    Location:285 → 458
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:381 → 453
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12636
    Location:17 → 97
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  8. NM_001381297.1 → NP_001368523.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARP1
    Conserved Domains (3) summary
    TIGR01661
    Location:285 → 456
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:379 → 451
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12636
    Location:17 → 97
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  9. NM_001381298.1 → NP_001368524.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU13
    Conserved Domains (2) summary
    cd12362
    Location:306 → 378
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12636
    Location:17 → 97
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  10. NM_001381299.1 → NP_001368525.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR37
    Conserved Domains (3) summary
    TIGR01661
    Location:243 → 416
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:339 → 411
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cl17169
    Location:39 → 55
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. NM_001381300.1 → NP_001368526.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUP5
    Conserved Domains (3) summary
    TIGR01661
    Location:243 → 414
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:337 → 409
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cl17169
    Location:39 → 55
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. NM_001381301.1 → NP_001368527.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AX10
    Conserved Domains (2) summary
    cd12362
    Location:264 → 336
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cl17169
    Location:39 → 55
    RRM_SF; RNA recognition motif (RRM) superfamily

  13. NM_001381302.1 → NP_001367869.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYR9
    Conserved Domains (1) summary
    cd12362
    Location:269 → 341
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  14. NM_001381303.1 → NP_001368528.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARP5
    Conserved Domains (2) summary
    TIGR01661
    Location:177 → 350
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:273 → 345
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  15. NM_001381304.1 → NP_001368529.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU17
    Conserved Domains (2) summary
    TIGR01661
    Location:177 → 348
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:271 → 343
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  16. NM_001381305.1 → NP_001368530.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR42
    Conserved Domains (1) summary
    cd12362
    Location:198 → 270
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  17. NM_001381306.1 → NP_001368531.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUQ1
    Conserved Domains (2) summary
    TIGR01661
    Location:101 → 274
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:197 → 269
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  18. NM_001381307.1 → NP_001368532.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AX15
    Conserved Domains (2) summary
    TIGR01661
    Location:101 → 272
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:195 → 267
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  19. NM_001381308.1 → NP_001368533.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARQ0
    Conserved Domains (1) summary
    cd12362
    Location:122 → 194
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

RNA

  1. NR_132573.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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